Musculoskeletal symptoms are extremely common, with almost one-third of people aged 75 years and over having a significant musculoskeletal problem. Joint pain due to inflammatory arthritis is important to identify, as it is potentially treatable. In elderly patients, inflammatory arthritis may not present in the ‘classical’ way, may present with non-specific symptoms and may co-exist with other musculoskeletal problems, all of which can result in diagnostic difficulty. In addition, co-morbid conditions and polypharmacy may present treatment challenges. In this paper, we discuss the general considerations in the clinical evaluation and management of a patient with inflammatory joint symptoms and discuss in more detail the diagnosis and management of the common causes of inflammatory arthritis.