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1 results

  • In vitro bioactivity and antibacterial properties of bismuth oxide modified bioactive glasses

  • Sakthi Prasad S, Itishree Ratha, Tarun Adarsh, Akrity Anand, Prasanta Kumar Sinha, Prerna Diwan, Kalyandurg Annapurna, Kaushik Biswas
  • Journal:
    Journal of Materials Research / Volume 33 / Issue 2 / 29 January 2018
    Published online by Cambridge University Press:
    04 December 2017, pp. 178-190
    Print publication:
    29 January 2018

  • Chronic osteomyelitis, a bone infection caused by bacteria, requires extensive parenteral treatments. With an aim to develop bioactive glass with antibacterial properties to resist such infections, bioactive glasses with bismuth oxide as the dopant in various amounts up to 8 wt% were prepared. X-ray diffraction patterns and Fourier-transform infrared spectra of glass samples after immersion in simulated body fluid showed the presence of hydroxyapatite (HAp) and hydroxyl carbonate apatite for all samples except with the one having Bi2O3 substitution of 8 wt%. In vitro cell proliferation by MTT assay studies using a mouse fibroblast cell line (NIH3T3) have also been carried out. Primary antimicrobial activity of the glass particles was analyzed against Escherichia coli (E. coli) using broth microdilution method which exhibited bacteriostatic effects and bactericidal properties in selected samples. The combination of bioactivity, cell proliferation, and antibacterial properties of selected Bismuth-containing bioactive glasses could be exploited in treating bone-related infections.