Field studies were conducted in 1990 and 1991 at Davis and Five Points, CA to evaluate weed control with napropamide and hand-weeding and the effect on yield and profitability in transplanted bell pepper. Weed cover 8 wk after transplanting averaged less than 10% in plots hand-weeded biweekly for 6 wk after transplanting. Weed cover at harvest was less than 30% in plots hand-weeded at 8 wk after transplanting. Napropamide treatment reduced weed cover at 8 wk after transplanting an average of 34% compared to untreated plots, but differences declined to 14% at harvest. Time required to hand-weed plots was greater if the interval between weeding was 4 instead of 2 wk. The time needed to hand-weed plots was reduced from 38% to 71% by napropamide treatment. When weeds were excluded by hand-weeding for the entire season, bell pepper yielded 25 810 kg/ha and was 4% to 18% higher than other treatments. Net returns were greater for plots that were hand-weeded the entire season or when napropamide was combined with hand-weeding at 4 and 8 wk after transplanting, compared to other treatments.