Reduced-rate zone herbicide application (ZHA) consists of banding reduced herbicide rates between crop rows (≤ full broadcast registered rate, 1×) and banding much reduced herbicide rates over crop rows (≪ 1×). The objective of this research was to compare the mechanically complicated dual-boom ZHA sprayer with a much simpler, single-boom ZHA sprayer for controlling giant foxtail and common waterhemp in field corn in 2003 and 2004 in Missouri. The dual-boom ZHA sprayer employed two different herbicide solutions, which were propelled through two booms on separate sprayer systems to apply different herbicide rates over in-row and between-row areas while maintaining similar carrier volumes and coverage through two booms. In contrast, the single-boom ZHA sprayer is a mechanically simpler system in which both herbicide rates and carrier volumes were varied across one boom over in-row (IR) and between-row (BR) areas. In single-boom ZHA, two different nozzle tips were alternated on one boom over in-row and between-row areas, the number of nozzles per boom was doubled, and the distance between nozzles was halved compared with a conventional sprayer boom. In a 2-yr study, these different ZHA sprayers were used to apply preemergence atrazine + S-metolachlor between and over crop rows at various reduced rates (1× = 2,240 + 1,750 g ai/ha, respectively). Among all single- and dual-boom ZHA sprayer treatments and the weed-free checks, corn yields and in-row total weed cover were statistically indistinguishable for both years and for between-row total weed cover in 1 of 2 yr. In both years, a single-boom ZHA system prevented yield loss from competing weeds as effectively as the dual-boom ZHA system. The new single-boom ZHA system is a mechanically simple, inexpensive, generic alternative for reducing herbicide rates and lowering input costs.