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antigenic drift

Animal Health Research Reviews (1)

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Avian influenza virus: prospects for prevention and control by vaccination
Chang-Won Lee, David L. Suarez
Journal:

Animal Health Research Reviews / Volume 6 / Issue 1 / June 2005

Published online by Cambridge University Press:

28 February 2007, pp. 1-15
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Although vaccination does not always prevent infection of avian influenza (AI) virus, the clear benefit of vaccination is in its ability to prevent disease and to reduce the amount of virus in circulation. Thus, judicious use of vaccination can be an important component of an AI control program. However, the long-term use of vaccination without eradication may result in the selection of the antigenically divergent strains, which compromises the value of vaccination. In this review, the effectiveness of currently available and future AI vaccines is discussed with suggestions for the ideal use of vaccination even with antigenic drift of the virus.