The differential imaging technique is particularly suitable for the
detection of small concentrations of contrasts agents for biological
and medical applications in samples using X-ray radiography. In this
paper, we present an application of this technique using a laser-plasma
soft X-ray source combined with a bent crystal. Using a Fresnel plate
as a test object, we were able to obtain spatial resolutions of the
order of a few tens of microns. The use of our configuration to perform
differential imaging of a test-sample at the L2 edge of Br
at 1,596 eV is finally demonstrated.