The year 2020 was marked by the COVID-19 pandemic that killed more than one million people. Scientists around the world are looking for an effective vaccine against this virus.

The objective of our study was to assess the acceptability of the COVID-19 vaccine by paramedics.

Descriptive and cross-sectional study including paramedics (nurses, orderlies) from the military hospital of Tunis. Data collection was carried out by a clinical psychologist. We studied the associations between the different characteristics of our population and the decision to accept or refuse vaccination against COVID-19.

A total of 161 paramedics agreed to answer our questionnaire. The average age was 37.73 years. The average number of years worked was 14.95 years. There were 85 women (52.8%) and 76 men (47.2%). The rapid discovery of the vaccine was hoped for by 94.4%. Vaccination was considered a means of collective protection by 84.5%. However, only 52.8% agreed to be vaccinated by the COVID-19 vaccine. The main factors significantly associated with refusal of the COVID-19 vaccine were previous refusal of influenza vaccination (p = 0.006).

Apprehension about vaccination does not appear to be sparing the future COVID-19 vaccine. To achieve vaccination coverage that would protect health care workers, several awareness and communication activities must be carried out.