This article examines the formative years of flight in the United States and argues that Pan-Americanism served as a guiding ideology in the development of the nation's early aeronautic endeavors. With the advent of the airplane at the turn of the twentieth century, U.S. Pan-Americanists believed that aviation would provide a solution to the sociological and practical problems that hindered the development of international unity among the American republics. By physically transporting individuals, products, and cultural media rapidly across the hemisphere via the sky, aircraft would unite the peoples of Latin America and the United States and promote inter-American cooperation. To see the Pan-American potential of aircraft fulfilled, Pan-Americanists cooperated with private U.S. aviation organizations to expound the value of flight and to generate interest in aviation across the Western Hemisphere. Although a variety of Pan-American initiatives were successfully undertaken during the 1910s, the outbreak of the First World War hindered the movement and ultimately led to the transformation of aviation into a tool of U.S. imperialism in Latin America. By examining the origins of U.S. aviation through the lens of Pan-Americanism, this article seeks to reevaluate the pervading imperial narrative of the history of U.S. aviation in the Western Hemisphere.