Sensitivity of 49 tomato cultivars and four weeds to DPX-E9636 was determined in greenhouse experiments. Cultivar tolerance varied from completely tolerant to intolerant. The most efficacious application method in greenhouse experiments was early POST for the weeds tested (yellow nutsedge, prostrate eclipta, and paraquat-resistant and -sensitive American black nightshade). Paraquat-resistant American black nightshade was 123 times more sensitive to DPX-E9636 than the paraquat-sensitive biotype. Under field conditions and at 0, 36, or 72 g ai/ha applied one week after transplanting, tomato cultivars showed no response to DPX-E9636 in visual vigor ratings 3 wk treatment, or in shoot fresh or dry weight 4 wk after treatment.