The present article describes an experimental study that is a part of an integrated theoretical (Rikanati et al.2003) and experiential investigation of the Richtmyer–Meshkov (RM) hydrodynamic instability that develops on a perturbed contact surface by a shock wave. The Mach number and the high initial-amplitude effects on the evolution of the single-mode shock-wave-induced instability were studied. To distinguish between the above-mentioned effects, two sets of shock-tube experiments were conducted: high initial amplitudes with a low-Mach incident shock and small amplitude initial conditions with a moderate-Mach incident shock. In the high-amplitude experiments a reduction of the initial velocity with respect to the linear prediction was measured. The results were compared to those predicted by a vorticity deposition model and to previous experiments with moderate and high Mach numbers done by others and good agreement was found. The result suggested that the high initial-amplitude effect is the dominant one rather than the high Mach number effect as suggested by others. In the small amplitude–moderate Mach numbers experiments, a reduction from the impulsive theory was noted at late stages. It is concluded that while high Mach number effect can dramatically change the behavior of the flow at all stages, the high initial-amplitude effect is of minor importance at the late stages. That result is supported by a two-dimensional numerical simulation.