Pitted morningglory control with norflurazon or fluometuron preemergence (PRE), each at 1.12 kg/ha, was 72% or less 14 d after a postemergence (POST) application of pyrithiobac in 1993 and 1994. Pyrithiobac POST at 70 g/ha following fluometuron or norflurazon PRE cultivated at any timing controlled pitted morningglory at least 76%. Pyrithiobac POST controlled common cocklebur equal to the weed-free in 1993 at 14 d after the POST application. In 1994, when rated 28 d after pyrithiobac POST, cultivation 3 d before a single application of pyrithiobac controlled less common cocklebur than any other herbicide treatment containing pyrithiobac. At 28 d after pyrithiobac POST, no treatment controlled common cocklebur as well as the weed-free. In 1993 and 1994, seed cotton yield was equal to the weed-free when pyrithiobac followed fluometuron PRE cultivated at any timing or a single application of pyrithiobac cultivated prior to 7 d after POST application.