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12 - The Importance of Phase 2 in Drug Development for Alzheimer’s Disease
from Section 3 - Alzheimer’s Disease Clinical Trials
- By Philip Scheltens, Willem de Haan, Roos J. Jutten, Everhard Vijverberg, Arno de Wilde, Niels Prins
Edited by Jeffrey Cummings, University of Nevada, Las Vegas, Jefferson Kinney, University of Nevada, Las Vegas, Howard Fillit
Book:

Alzheimer's Disease Drug Development

Published online:

03 March 2022

Print publication:

31 March 2022, pp 150-161
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Summary

Phase 2 in drug development is a crucial phase that can make or break success. The goals in Phase 2 are to determine safety, dosage and efficacy. In this chapter elements of planning, design, biomarker use and clinical outcomes are highlighted and some good and bad examples are given, emphasizing the importance of conducting a proper Phase 2.