For fisheries with multiple, competing objectives, identifying and applying reference points for management can present difficult trade-offs between long-term biological and shorter-term socioeconomic considerations. The term biological benchmarks is proposed to demarcate zones of population status based on conservation and production considerations. These scientifically derived benchmarks contrast with management reference points that generally require additional shorter-term socioeconomic information best obtained through public consultations. This paper illustrates the distinction between biological benchmarks and management reference points with a case study on Pacific salmon (Oncorhynchus spp.). In Canada, the management and assessment of wild Pacific salmon are guided by a major 2005 conservation policy, which calls for the identification of biological benchmarks to categorize status of demographically isolated populations, and decision-support tools, such as management reference points, to integrate biological information with appropriate social and economic information. In the Fraser River (British Columbia, Canada), the selection of management reference points for sockeye salmon (O. nerka) fisheries explicitly considered trade-offs between the probability of meeting long-term biological objectives on component populations and harvest objectives on population aggregates. Decisions about reference points were made in a consultative process that included extensive stakeholder engagement. Other agencies are urged to distinguish biological benchmarks from management reference points to ensure transparency in the relative influence of biological versus socioeconomic information in decision making.