This chapter comes in two related but distinct parts. The first presents general trends in the neurosciences and considers how these impact upon psychiatry as a clinical science. The second picks up a recent and important development in neuroscience which seeks to explain mental functions such as perception and has been profitably extended into explanations of psychopathology. The second part can be viewed as a working example of the first’s overarching themes.

The focus of this chapter is how the material body is represented in the brain. The aim is to demonstrate the neural mechanisms underpinning body representation in order to show how the sense of self is experienced as embodied. Furthermore, given the underlying mechanisms underpinning the integration of self and body, how to understand the possibility of a separation of self and body as seen in autoscopy. I rely on the experiments of Olaf Blanke and his group in this regard.

“Writing Is a System” debunks the popular view that writing is an art, best learned by reading selections of good writing and practicing composing. Instead, writing is a system that involves understanding what factors make sentences seem easy to read and paragraphs well organized. This chapter also examines the relevance of readability scores in assessing writing.

Hierarchical situations are a complex example for determining individual responsibility, as typically a superior communicates a plan, and a subordinate executes it. Thus, the superior bears responsibility for the decision but is distanced from the outcomes, while the subordinate experiences authorship over the action but may not experience responsibility for its outcomes. This chapter focuses on how authority is wielded and how decisions are made by commanders in order to understanding the dynamics of obedience. By reviewing the claims made by some leaders of genocide, this chapters show that despite their high position in the hierarchical chain, they are frequently trying to reduce their responsibility for the atrocities conducted. Neuroscience research further showed that giving orders leads to a reduction of the sense of agency and moral emotions towards the pain of victims. These results show how hierarchical situations can allow people to commit actions that could transgress moral conducts, as agency and moral emotions are split across two individuals.

The “just following orders” argument has been used across many documented wars and genocides around the world. It suggests that the justifications given by perpetrators perhaps reflect, at least in part, a reality in their brains that would be shared across all the members of our species. The brain is a complex structure composed of trillions of neurons that controls our thoughts, our feelings, our decisions, our memory, our senses, and that regulates our body. Even though a wide range of environmental and social factors can modulate how our brains process information and computes decisions, the brain is nevertheless the central processing agent. By providing a novel perspective on what is happening in the brains of those obeying orders, I seek to reveal the mechanisms leading to immoral behaviors under obedience at a deep and individual level – that is, at the neural level. This knowledge can be used to develop personalized interventions that take into account unique neurobiological profiles.

This chapter focuses on the individuals who actively worked to protect and save members of targeted groups during genocides, often at great personal risk. By presenting sociological, psychological, and neuroscience research designed to understand better the profile of those who risked their lives to rescue strangers in times of war, this chapter asks what makes this small subset of the population react differently than others. By combining research and interviews with rescuers, the chapter shows that both individual processes and environmental factors contribute to risking one’s own life to rescue threatened human beings. People who engaged in rescue efforts during a particular event came from a range of different backgrounds, and no single factor can be reliably used to predict why they chose to help. Some rescuers were motivated by their religious or moral beliefs, while others were motivated by empathy or a desire to protect. The chapter also argues that even though rescuers are not numerous, they are nonetheless a living examples that another choice is possible, and that human beings may find the strength to overcome hateful propaganda. This raises hope of developing efficient interventions aimed at reducing susceptibility to blind obedience.

Humans have the ability to recognize that when they perform actions, they produce effects in the external world. Even though humans are not the only animalsl with this mental capacity, their ability to perform actions is accompanied by a feeling of authorship, a feeling that “I” am the one who did it. This is what academics have called the sense of agency. When individuals claim reduced responsibility because they were “only obeying orders”, this defense is often viewed with skepticism, because the defendant has a clear motive of avoiding punishment. However, scientific methods can now be used to investigate the experience of receiving orders and how it influences how the brain processes information. As this chapter shows, obeying orders impacts the sense of agency and the feeling of responsibility at the brain level. Further, working and living in some highly hierarchical and sometimes coercive social structures, such as the military, can also impact the sense of agency when people make decisions. It thus appears that hierarchies provide a powerful ground to obtain a reduced feeling of responsibility and agency in individuals.

When we witness another person experiencing pain, be it emotional or physical, we have an empathic reaction. And even if we commit a harmful action against another person, we most of the time experience guilt in the aftermath, which prevents us from performing the same action in the future. Guilt and empathy are critical moral emotions that together usually prevent us from harming others. However, as this chapter shows, systematic processes of classification and dehumanization at play before a genocide can alter moral emotions towards another part of the population. Activity in empathy-related brain regions is generally reduced towards individuals that we consider as outgroup or towards dehumanized individuals. Neuroscience studies have further shown that when obeying orders to hurt another person, neural activity in empathy- and guilt-related brain regions is reduced compared to acting freely. Such results show how obeying orders diminishes our aversion to harming others.

Wars and genocides only bring desolation. Of course, we first think about the dramatic psychological consequences of those who survived extermination or those who have witnessed their families and friends being killed or mutilated. Psychological and neuroscience research have shown that surviving a psychological trauma leaves long-lasting imprints on individuals with notable life-long post-traumatic stress disorder (PTSD) symptoms, which can also extend to the following generations. Importantly, the psychological disaster observed in the aftermath of a war or a genocide not only touches the victims, their relatives, or their descendants. It also has disastrous consequences on the mental health of the assailants. The chapter argues that in order to stop the cycle of conflicts, we must also understand how both victims and assailants are impacted at the psychological level by their respective experience, and how to help them overcome their demons and potential feelings of revenge. Taking care of their mental health is a step towards stopping cycles of conflict.

The genome is the totality of information that directs the making and the maintenance of you and every other living organism. Scattered among the familiar genes that code for the proteins of life are other genes. This is a book about the genes we call microRNA. It is 30 years since their discovery. They are gene regulators, every bit as vital as their more famous gene cousins. MicroRNAs fine-tune how much protein is made in our cells, each one coordinating the activity of hundreds of genes and bringing precision to the ‘noise’ of gene expression. Without them, life is virtually impossible. This introduction provides a personal account of what fascinated the author about these genes enough to make him redirect his research to microRNAs. The journey from studying pharmacology in the UK, to the USA where his interest in the brain disease epilepsy began, and later to Dublin, to work at the Royal College of Surgeons in Ireland. It lays out the contents and style of the book, which is part history of science, describing what we know and the experiments that underpin our understanding, and part memoir of the author’s own research, and the applications of microRNAs in medicine.