Intermediate levels of social organization—above the household but below the entire settlement, city, or polity—are notoriously difficult to pinpoint in archaeological contexts, but they nevertheless represent a crucial frontier for building new archaeological theory to understand daily social life in the past. Ethnographic research demonstrates that informants recognize units such as the “neighborhood” and consider them important. In Mesoamerica, organizational units such as the Mixtec siqui, Aztec calpulli, and Maya cuchcabal were often formally recognized in social, military, and economic systems. Here, a neighborhood case study is presented from San Pedro Teozacoalco in Oaxaca, Mexico. The site known as Iglesia Gentil, which is located atop a mountain today called Cerro Amole, was the cabecera, or administrative center, of Chiyo Cahnu, an important Postclassic Mixtec polity. Using distributions of architecture and artifacts across the site based on data collected with GPS units from 2013 to 2017, three complementary GIS-based models are evaluated for their ability to define neighborhoods at Iglesia Gentil. The best is based on least cost paths modified by Tobler's hiking function.