This study asks how human trafficking in Ming China (1368–1644) became enveloped in the emerging global economy of the sixteenth century. Utilizing theoretical insights from the model of “slaving zones,” the essay examines recorded incidents of human trafficking along China’s littoral from 1370 to 1565 and contends that its presence and persistence were intertwined with the Ming court’s economic policies and problems. Here the history of human trafficking in early-to-mid-Ming China is viewed from the perspective of a series of challenges to the country’s economic well-being but also to its power to govern according to its own laws and norms. These challenges include the Ming regime’s efforts: to eradicate piracy and smuggling through their integration into the lawful framework of tribute trade; to support provincial requests for extra revenue to promote military security; to acquire Japanese silver but deny Japan mercantile access to China; to profit from Portugal’s Southeast Asian and Japanese commercial networks. This study argues that the increasing prevalence of human trafficking along China’s coastline was the result of competing forces anxious for power and riches that fused into the thrust of sixteenth-century China’s expanding economy, as well as the adaptability of those in authority to ignore the consequences of allowing safe havens for persons bartering and selling human beings. These factors turned the status of Ming China’s littoral from a “no slaving zone” into an “imperfect no slaving zone.”