Soil–alkali interaction leads to abnormal soil behavior due to significant changes in mineralogy and morphology. The effect of alkali on the swelling behavior of natural clays has been explored in recent years, but the swelling behavior of alkali-transformed clay minerals is still unclear. The objective of the current study was to investigate the effect of alkali concentration on swelling characteristics of natural and alkali-transformed kaolinitic clays. The study was complemented further with micro-level investigations. Red earth and kaolin, which are regarded as non-swelling kaolinitic clays, were utilized. The results showed that alkalis induced greater swelling in natural clays than in alkali-transformed clays. The results revealed further that alkali-transformed clays exhibited decreases in swelling when exposed to increased alkali concentrations. Moreover, the degree of transformation played an important role in the swelling behavior of alkali-transformed kaolinitic clays when inundated with water and with various alkali concentrations. These variations may be attributed to the different extents of mineralogical and microstructural changes caused by alkali treatment.