Field trials were conducted in 2009 and 2010 near Paterson, WA and Ontario, OR to evaluate weed control and potato tolerance to PRE-applied pyroxasulfone, saflufenacil, and KSU12800 herbicides. Pyroxasulfone at 0.09 to 0.15 kg ai ha−1 and saflufenacil at 0.05 to 0.07 kg ai ha−1 applied PRE alone or in tank mixes with several currently labeled herbicides did not injure potatoes at either site in both years. KSU12800 at 0.15 kg ai ha−1 injured potatoes from 18 to 26% for a period of about 4 wk after emergence at Ontario both years. In addition, KSU12800 at 0.29 and 0.45 kg ha−1 injured potatoes from 17 to 38% at 17 d after treatment (DAT) at Paterson in 2009. Pyroxasulfone at 0.15 kg ha−1 controlled barnyardgrass, hairy nightshade, and redroot pigweed 96% or greater, but control of common lambsquarters was variable. Saflufenacil at 0.07 kg ha−1 provided greater than 93% control of common lambsquarters, hairy nightshade, and redroot pigweed at both sites in 2010. KSU12800 at 0.15 kg ha−1 controlled common lambsquarters, hairy nightshade, and redroot pigweed 99% or more at Ontario, but only 87 to 93% at Paterson in 2010. These herbicides did not reduce yield of U.S. no. 1 tubers or total tuber yields compared to standard labeled herbicide treatments when weed control was adequate.