Complex global problems, such as sustainable crop production, where conventional products do not fully solve the problem due to their low efficacy and negative environmental impact, require rationally designed products. Generally, these products are based on efficient technologies and stimuli-responsive and high-performance materials. Considering the product design approach with a science-based approach such as drug development through QbD. We propose to merge the most relevant elements of these approaches in an integrated design methodology. Regarding the conceptual analysis, we propose two phases: initially, an early phase with conceptual solutions, followed by an advanced phase based on QbD elements to define the research hypothesis. Hence, optimal product conditions defined in the design space must comply with the required performance of the stimuli-responsive product. So, with this proposed integration we pretend to potentialize and strengthen the established tools for product design, achieving an advanced and robust design methodology.