Postemergence herbicides used to control weeds in the space between raised, plastic-covered beds in plasticulture production systems are typically banded, and herbicides are applied to weeds and to where weeds do not occur. To reduce the incidence of off-targeted applications, the University of Florida developed a smart-spray technology for row middles in plasticulture systems. The technology detects weed according to categories and applies herbicides only where the weeds occur. Field experiments were conducted at the Gulf Coast Research and Education Center in Balm, FL, in fall 2021 and spring 2022. The objective was to evaluate the efficacy of postemergence applications of diquat and glyphosate in row middles in jalapeno pepper fields when banded or applied with smart-spray technology. The overall precision of the weed detection model was 0.92 and 0.89 for fall and spring, respectively. The actuation precision achieved was 0.86 and 1 for fall and spring, respectively. No significant differences were observed between banded and targeted applications either with glyphosate or diquat in terms of broadleaf, grass, and nutsedge weed density. No significant pepper damage was observed with either herbicide or application technique. The smart-spray technology reduced herbicide application volume by 26% and 42% in fall and spring, respectively, with no reduction in weed control or pepper yield compared to a banded application. Overall, the smart-spray technology reduced the herbicide volume applied with no reductions in weed control and no significant effects on crop yield.