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1 results

  • In vitro activities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

  • G Yenişehirli, Y Bulut, M Güven, E Günday
  • Journal:
    The Journal of Laryngology & Otology / Volume 123 / Issue 9 / September 2009
    Published online by Cambridge University Press:
    20 May 2009, pp. 978-981
    Print publication:
    September 2009
  • Objective:

    To determine the causative pathogens of otomycosis, and to evaluate the in vitro activity of antifungal agents against these pathogens.

    Materials and methods:

    A total of 96 fungal isolate were taken from 92 patients suspected of otomycosis. The in vitro activity of fluconazole, itraconazole and voriconazole against otomycotic pathogens was tested using the E-test method.

    Results:

    The most common pathogen was Aspergillus fumigatus (40.6 per cent), followed by A niger (35.4 per cent), A flavus (12.5 per cent) and Candida albicans (11.5 per cent). All Aspergillus species were found to be resistant to fluconazole (minimum inhibitory concentration ≥256 µg/ml). The mean minimum inhibitory concentrations of voriconazole for A fumigatus, A niger, A flavus and C albicans were significantly lower than those of itraconazole for the same pathogens.

    Conclusion:

    This study found that the most common otomycotic fungal pathogen was A fumigatus, and that voriconazole had more potent in vitro activity than itraconazole against all Aspergillus species as well as against C albicans.