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1 results

  • 16 - Biomarker Discovery Study 1

  • from Part V - Multivariate Biomarker Discovery Studies
  • Darius M. Dziuda, Central Connecticut State University
  • Book:
    Multivariate Biomarker Discovery
    Published online:
    30 May 2024
    Print publication:
    06 June 2024, pp 221-240

  • Summary

    Chapters 16 presents the first of the two real-life multivariate biomarker discovery studies included in the book. The goal of this study – which implements the method presented in Chapters 14 and 15 – is to identify the essential gene expression patterns and a multivariate biomarker common for multiple types of cancer. This study is based on the TCGA RNA-Seq data of 3,528 patients and 20,530 gene expression variables; the data represent five tumor types of five different tissues. A parsimonious multivariate biomarker (consisting of ten genes) with high sensitivity and specificity has been identified.