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2 results

  • Surgical management of amiodarone-induced thyrotoxicosis in a patient with Eisenmenger's syndrome: literature review and case report

  • R Pratap, A Qayyum, N Ahmad, P Jani
  • Journal:
    The Journal of Laryngology & Otology / Volume 123 / Issue 11 / November 2009
    Published online by Cambridge University Press:
    02 December 2008, pp. 1276-1279
    Print publication:
    November 2009
  • Objective:

    We present a patient with a rare combination of amiodarone-induced thyrotoxicosis and Eisenmenger's syndrome.

    Method:

    Case report and review of the world literature regarding the morbidity and mortality of surgical management of amiodarone-induced thyrotoxicosis and the potential hazards of non-cardiac surgery in patients with Eisenmenger's syndrome.

    Results:

    Failure of maximal medical therapy necessitated surgical management to treat amiodarone-induced thyrotoxicosis which, in this particular patient, carried significant risks. Total thyroidectomy was performed leading to rapid resolution of thyrotoxicosis, and the patient made an uncomplicated recovery. We present this case because of its rarity and the potentially hazardous nature of surgical intervention in patients with Eisenmenger's syndrome. The pathogenesis of amiodarone-induced thyrotoxicosis and the differing approaches of medical and surgical management are discussed.

    Conclusion:

    Based on our findings, we propose that surgical management should be considered earlier in the treatment algorithm (or possibly as first-line therapy) for amiodarone-induced thyrotoxicosis.

  • Current management of ventricular septal defect

  • Henry M. Sondheimer, Kristy Rahimi-Alangi
  • Journal:
    Cardiology in the Young / Volume 16 / Issue S3 / September 2006
    Published online by Cambridge University Press:
    13 October 2006, pp. 131-135

  • At this time, the current practice for treatment of patients with isolated ventricular septal defect is infrequently studied. With this in mind, it was our intent to assess the current management of ventricular septal defect at a single center, The Children's Hospital, Denver. We reviewed the practice at this institution to determine if there is an evidence base for when or if a patient with an isolated ventricular septal defect requires surgical repair. With approval from the Colorado Multiple Institutional Review Board (protocol # 06-0097), we reviewed the data on patients with isolated ventricular septal defect seen during the calendar years of 2004 and 2005, determining the state of the patients, and the level of intervention through December 31, 2005.