Egg Drop Syndrome 1976 (EDS- 76) is a viral disease of laying birds characterized by a sudden drop in egg production, failure to achieve peak production and the laying of poor quality eggs. It has been reported to affect a wide range of birds including turkeys and layers and is a major constraint to the profitability of egg production in both commercial and village laying birds. This paper is a review of the epidemiology of EDS-76 virus infection in various species of poultry in Nigeria, with emphasis on the susceptibility of species, types and ages. Also examined are the economic impacts, challenges and prospects of EDS-76 virus management and control. This review will be of assistance in the formulation of an effective strategy for proper management and control of the disease in the field.