This study was undertaken to investigate the integration effects of pretilachlor, oxadiazon, and dimethenamid with or without glyphosate in a stale seedbed method to control weedy rice in wet-seeded rice. The study, conducted in 2018 and 2019, comprised two seedbed treatments in main plots, with and without glyphosate (850 g ae ha−1), and four subplot treatments: pretilachlor, oxadiazon, dimethenamid, and unsprayed check. Fifteen days after glyphosate spray, each subplot was treated with preemergence herbicides at 500 g ai ha−1 under standing water conditions (2 to 3 in.), and the water level was maintained for 7 d. Pregerminated rice seeds (var. MR297) were hand-broadcasted in the moist soil at 120 kg ha−1 seeding rate. In 2019, the density and dry weight of weedy rice were 30% and 118% higher Gthan those observed in 2018, respectively. A stale seedbed with glyphosate reduced weedy rice dry weight by 12% as compared to what was observed in a stale seedbed without glyphosate. Addition of oxadiazon and pretilachlor to the stale seedbed drastically reduced weedy rice dry weight by 70% to 88% and 53% to 60% in both years. Dimethenamid contributed to a significant reduction of weedy rice dry weight of 19% in 2019 only but failed to provide a positive economic return. Integration of pretilachlor and oxadiazon in a stale seedbed with glyphosate gave profitable returns of $84.00 to 311.4 ha−1 and $175.70 to 483.8 ha−1, respectively. Without the presence of glyphosate, pretilachlor and oxadiazon contributed a positive return of $318.90 and $469.40, respectively, in 2018, but the economic returns were negative in 2019. These results suggest that integration of pretilachlor or oxadiazon in a stale seedbed with glyphosate is more crucial when weedy rice infestation is high, but glyphosate can be excluded from the management regime when the weedy rice populations are low.