Studies were conducted to determine the effect of interference between tropic croton (Croton glandulosus) and cotton (Gossypium hirsutum) on plant growth and productivity. Tropic croton height was not affected by weed density, but cotton height decreased with increased weed density 10 wk after planting. Tropic croton biomass per plant was not affected by weed density, but total weed biomass per meter of crop row increased with weed density. Cotton lint yield decreased linearly 2 kg ha−1 with each gram increase in weed dry biomass per meter of row. Percent yield loss–density relationship was described by the rectangular hyperbola model. Estimated coefficients A (maximum yield loss) and I (yield loss per unit density as density approaches zero) were 129.6 ± 42.2 and 35.6 ± 8.0%, respectively, when asymptotic iterations were based on least sums of squares. When A was constrained to 100% yield loss, I was 42.5 ± 5.1%. Results indicated that tropic croton was less competitive with cotton than many weeds but represents an economic threat to cotton growers.