This chapter discusses how strategic philanthropy, especially for neglected health issues such as palliative care, can help improve quality of life for patients and their families. It defines palliative care as responsive care. It is care that begins from the diagnosis of any serious illness, for both children and adults. Palliative care aims to address the pain and other symptoms related to the physical, social, and spiritual needs of both the patient and their family. The chapter showcases the work of Cipla, an Indian pharmaceutical company committed to supporting this proof of concept. In 1997, Cipla’s philanthropic capital was deployed to build a Palliative Care and Training Centre which remains the nucleus of the palliative care effort even today. Cipla’s commitment to palliative care has continued to grow and develop resilience over the past three decades. The chapter outlines how the three key elements of supporting direct services, training health-care providers, and engaging in national-level collaborations for policy change have helped build a system and approach that is sustainable and future-proofed. In showcasing the work of Cipla, this chapter shows how, by making sustainable changes to the palliative care ecosystem and developing an integrated model of care within the public health care system, philanthropic capital has been able to align with government priorities and attract more philanthropists to this space. This chapter elaborates how the vision of palliative care has been promoted across India and illustrates how strategic giving can focus on a neglected issue and work towards sustainable change.