Field studies were conducted at two locations in 1997 and 1998 to evaluate crop injury, weed control, yield, and net economic returns of single and sequential postemergence applications of labeled and reduced rates of glyphosate to no-till, glyphosate-resistant soybean planted in narrow rows. Sequential applications provided at least 91% control of giant foxtail, while single applications provided at least 86% control with labeled rates and 68–93% control with reduced rates. Common waterhemp control was slightly higher with sequential vs. single treatments and with labeled rates vs. reduced rates. Velvetleaf control was greater than 96% with all treatments. Common cocklebur control was 90% or higher with all treatments except a single application of glyphosate at 210 g/ha. Lower control of giant foxtail and common waterhemp with single-application, reduced-rate treatments in two of the four trials resulted in lower yields. Overall, sequential applications, regardless of rate, provided greater weed control, yield, and net income and lower coefficients of variation (C.V.s) of net income than reduced-rate single applications. Single-application treatments showed a trend of decreased weed control, yield, and net income and higher C.V.s of net income with reduced rates of glyphosate.