COVID-19 has stimulated calls for a ‘global reset’ to address major global challenges and ‘build back better’. This Intelligence Briefing makes the case that the experience of COVID-19 itself, particularly the way it reverberated across multiple systems, shines light on the vital steps needed to advance a global reset. It brings together the evidence that the causes, severity and effects of COVID-19 cut across multiple interconnected systems, notably environmental, health, political, social, economic and food systems, as did the responses to it. All of these systems affected each other: responses implemented to address problems in one system inevitably led to effects on others. This Intelligence Briefing uses this evidence to identify five practical steps needed to advance a global reset. First, train systems leaders. Second, employ a new cadre of ‘systems connectors’. Third, identify solutions across systems. Fourth, manage trade-offs for the long and short term. Fifth, kick-start system redesign for co-benefits. Implementing these steps will be extraordinarily challenging, especially given the short-term imperative to ‘bounce back’. But for any business, organization, government or United Nations agency serious about addressing long-term sustainability challenges, the opportunity is there to use these five practical actions to press the global reset button.