To manage anaerobic digestion residues (digestate) sustainably, it is important to determine their agricultural properties. In the present study, the effects of two digestate fractions (solid and liquid) on processing tomato yield parameters, quality traits, health-related compounds and some fruit physiological disorders were evaluated. The solid and liquid digestate fractions were compared with chemically fertilized and unfertilized control to evaluate the potential of the digestate as a fertilizer. A 2-year experiment was conducted in a randomized complete block design, with three replications and using two tomato varieties: cv. ‘Arte F1’ and cv. ‘Zeplin F1’. The results indicated that (1) compared with chemical fertilizer, the solid digestate produced equal or even better results in terms of fruit size, yield parameters (solid digestate treatment increased the total fruit weight per plant by an average of 30.7, 8.2 and 22.4% in 2019 and 25.3, 14.2 and 17.9% in 2022 compared with control, chemical fertilizer and liquid treatments, respectively) and percentage of fruit affected by sunscald and blossom-end rot in both years; (2) use of liquid digestate led to similar or significantly higher fruit size, yield parameters and percentage of fruit affected by sunscald and blossom-end rot than control in both years and (3) use of both solid and liquid digestate fractions significantly maintained or improved fruit quality in terms of colour traits, pericarp thickness, dry matter content, total soluble solid content, titratable acidity, pH, vitamin C and antioxidant activity. However, the effects of solid and liquid digestate fractions varied with year and variety.