Mature visual cortex shows a single, binocularly matched
orientation map. This matching develops without visual experience.
It persists despite early monocular deprivation that largely
eliminates one eye's map, followed by reverse suture
(deprivation of the previously open eye and opening of the
previously deprived eye), even though the two eyes lack common
visual experience in this case. These results have been interpreted
to suggest that the structure of orientation maps either is
innately predetermined or, if it arises through self-organization,
is determined by external cues such as boundary conditions or
a “scaffolding” of horizontal connections. We show,
to the contrary, that these results are the expected outcomes
if orientation maps develop through activity-instructed,
correlation-based development of the geniculocortical connections
without additional cues. A weak, binocularly correlated orientation
map is known to exist before deprivation onset; we previously
showed how this can arise through activity-instructed development.
Now we show that this initial correlation between the two
eyes' maps can persist or increase despite deprivation
sufficient to cause massive loss of the deprived eye's
geniculocortical synaptic strength, followed by reverse suture.
Given sufficient early correlated map development, each map's
fate is “dynamically committed”: the two eyes'
maps will converge upon a common outcome, even if developing
independently. This dynamic fate commitment is retained even
after severe deprivation.