Beginning with the profound geopolitical changes created by the dissolution of the Austro-Hungarian monarchy and the creation of the Czechoslovak and Yugoslav states, this article examines how medical knowledge about maritime climate and sea-based therapies was mobilized in Czech popular touristic writing about Yugoslavia's Adriatic coast in the 1920s. The analysis of archival documents as well as non-specialist medical publications of Czech or Prague-trained doctors show that Czech tourists and curists (travelers in search of health treatments) were offered a freeform, all-encompassing therapeutic environmental approach. Inspired by Neo-Hippocratic principles, doctors stressed the importance of factors such as salt water, clean air, temperature variation, sunshine, flora, and modern facilities for disease prevention or the restoration of one's health. These doctors’ relative success in promoting the therapeutic virtues of the Adriatic Sea is explained in large part, this article argues, by a broad nexus of intertwined interests (such as the growth of tourism, concerns about public health, and the influence of Neo-Slavism) embedded in the project of transforming the Adriatic Sea into a therapeutic site.