Archaeological sites of the Mediterranean region are widely colonized by weed species causing various problems both to the monuments and the functionality of the sites. Due to recent regulatory restrictions for herbicide use at archaeological sites, flame weeding was studied as an alternative weed management method. The objective of the study was to test two propane doses (99 kg ha−1 and 129 kg ha−1) applied two, three, or four times at three archaeological sites of Greece (Kolona, Ancient Messene and Early Christian Amfipolis). Percent weed control and weed heights were significantly affected by flaming treatments. Visual evaluation of percent weed control suggested that the propane dose of 129 kg ha−1 applied four times provided excellent weed control (>90%) for over 2 months. Annual broadleaf weeds were controlled better with flaming than grasses and perennial broadleaf species. The high propane dose applied four times reduced average vegetation height to about 10 cm, which was the desirable vegetation height wanted by the managers of the archeological sites suggesting that flame weeding has the potential to be used effectively for weed management in archaeological sites of the Mediterranean region.