This article deals with the Protocol on Amendments to the Protocol on the Statute of the African Court of Justice and Human Rights. In particular it analyzes the legal issues arising from the jurisdiction of the court’s proposed International Criminal Law Section over corporations. After underlining the historic opportunity represented by this initiative, the author points out a number of challenges that will necessarily arise when the court begins to operate. These problems are mainly related to the fact that criminal law has developed around the criminal liability of natural persons. Overcoming these challenges will require rethinking how to apply many of the basic principles that traditional criminal law has, until now, taken for granted.