The Landscape Species Approach is a framework developed by the Wildlife Conservation Society for planning landscape-scale conservation based on a suite of focal species. The approach has so far been implemented at 12 terrestrial and two marine sites. We demonstrate the approach using two sites, the Adirondack Park, USA, and San Guillermo-Laguna Brava Landscape, Argentina. We describe the spatially explicit components, including steps to map the attainable (Biological Landscape), current, and future distribution of Landscape Species, human activities (Human Landscapes) and their impacts on Landscape Species, the possible impacts of conservation actions (Conservation Landscapes), and a procedure to set spatial conservation priorities. We discuss advantages and innovations of the approach, including how it incorporates both vulnerability of biodiversity and possible recovery. Finally, we discuss improvements that can be made to the approach, costs, and implications for conservation at the two sites.