Climate change is increasingly recognized as a significant driver of emerging infectious diseases, with the potential to catalyze the next global pandemic. This paper explores the complex interplay between climate change and the emergence of novel pathogens, emphasizing the environmental, ecological, and socio-economic factors that contribute to disease transmission. Rising temperatures, altered precipitation patterns, and habitat destruction are reshaping ecosystems, bringing humans into closer contact with zoonotic reservoirs and vectors. These changes amplify the risk of spillover events, as seen in recent outbreaks. The study identifies key challenges, including inadequate surveillance systems, limited global cooperation, and the disproportionate impact on vulnerable populations. Furthermore, it proposes adaptive measures such as enhanced early warning systems, integrated One Health approaches, and climate-resilient public health infrastructure. By addressing these challenges and implementing proactive strategies, the global community can mitigate the risk of a climate-driven pandemic and strengthen preparedness for future health crises. This paper underscores the urgent need for interdisciplinary collaboration and policy innovation to safeguard global health in the face of a changing climate