This study analyzes 2022 data from SAMHSA’s Mental Health Client-Level Data (MH-CLD) to investigate ADHD prevalence and comorbidity. The findings reveal that 10.70% of the 5,899,698 patients were diagnosed with ADHD, indicating a high demand for targeted resources. ADHD prevalence declines with age, highest in children aged 0–11, and decreases with educational attainment, emphasizing the need for early intervention. Employment challenges are significant, with the highest ADHD prevalence among those not in the labor force. Racial disparities show Black individuals have the highest ADHD rates (9.71%) and Asian individuals the lowest (5.05%). Geographic differences indicate higher prevalence in the Midwest and South. Gender disparities and marital status also influence prevalence, with males and never-married individuals showing higher rates. ADHD shows strong comorbidity with oppositional defiant disorder, pervasive developmental disorder/autism spectrum disorder and conduct disorder. Effective ADHD management requires collaborative efforts from educators, employers, healthcare providers and policymakers to create supportive environments and tailored approaches considering demographic variables, comorbid conditions and socioeconomic factors.