Observational effort is on the way to probe the 21-cm of neutral hydrogen from the epochs of Reionization and Cosmic Dawn. Our current poor knowledge of high redshift astrophysics results in a large uncertainty in the theoretically predicted 21-cm signal. A recent parameter study that is highlighted here explores the variety of 21-cm signals resulting from viable astrophysical scenarios. Model-independent relations between the shape of the signal and the underlying astrophysics are discussed. Finally, I briefly note on possible alternative probes of the high redshift Universe, specifically Fast Radio Bursts.