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Recurrent respiratory papillomatosis disease course in immunosuppressed populations

Published online by Cambridge University Press:  25 October 2023

Ericka L Erickson Open the ORCID record for Ericka L Erickson [Opens in a new window] ,
Taylor E Freeman ,
Shuai Sun ,
Brandon Koch ,
David Z Allen ,
Rishabh Sethia ,
Brad deSilva  and
Laura Matrka
Ericka L Erickson*
Affiliation:
Ohio State University College of Medicine, Columbus, OH, USA
Taylor E Freeman
Affiliation:
Ohio State University Wexner Medical Center, Columbus, OH, USA
Shuai Sun
Affiliation:
Ohio State University Department of Public Health, Columbus, OH, USA
Brandon Koch
Affiliation:
Ohio State University Department of Public Health, Columbus, OH, USA
David Z Allen
Affiliation:
University of Texas Health Science Center at Houston, Houston, TX, USA
Rishabh Sethia
Affiliation:
Ohio State University Wexner Medical Center, Columbus, OH, USA
Brad deSilva
Affiliation:
Ohio State University Wexner Medical Center, Columbus, OH, USA
Laura Matrka
Affiliation:
Ohio State University Wexner Medical Center, Columbus, OH, USA
*
Corresponding author: Ericka Erickson; Email: Ericka.erickson@osumc.edu
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Abstract

Objective

Recurrent respiratory papillomatosis is a benign manifestation of human papillomavirus types 6 and 11 in the respiratory tract. Disease is recurrent, and factors predicting these recurrences and severity of disease are incompletely characterised. This retrospective cohort study examined the relationship of immunosuppression with recurrent respiratory papillomatosis morbidity.

Methods

A retrospective cohort of 97 adult patients with recurrent respiratory papillomatosis treated at a tertiary referral centre from 2005 to 2020 was conducted. Measures assessed included inter-surgical interval, Voice Handicap Index (‘VHI-10’) and anatomical Derkay scores.

Results

Bivariate analyses comparing average inter-surgical interval, Voice Handicap Index and Derkay scores in immunosuppressed and healthy patients were insignificant. When controlling for diabetes mellitus and comparing immunosuppressed to healthy patients, inter-surgical interval and Voice Handicap Index change were insignificant (p = 0.458 and p = 0.465, respectively).

Conclusion

Recurrent respiratory papillomatosis morbidity for immunosuppressed patients did not significantly differ from that of immunocompetent patients.

Keywords

Laryngeal diseasesimmunosuppressiondiabetes mellitushuman papillomavirus
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 5 , May 2024 , pp. 576 - 580
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Ericka Erickson takes responsibility for the integrity of the content of the paper

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