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Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007–2012

Published online by Cambridge University Press:  12 November 2024

Lin Chen Open the ORCID record for Lin Chen [Opens in a new window] ,
Yaqian Mao  and
Gang Chen
Lin Chen*
Affiliation:
Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital South Branch, Fujian Provincial Hospital, Fuzhou, People’s Republic of China
Yaqian Mao
Affiliation:
Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital South Branch, Fujian Provincial Hospital, Fuzhou, People’s Republic of China
Gang Chen
Affiliation:
Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, People’s Republic of China
*
*Corresponding author: Lin Chen, email fjsljscl@outlook.com
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Abstract

Oxidative stress may be involved in the progression of hypothyroidism in patients with Hashimoto thyroiditis (HT). Vitamin C is a well-known powerful antioxidant. To our knowledge, whether vitamin C intake relates to hypothyroidism in patients with HT remains unclear. In this cross-sectional study based on the National Health and Nutrition Examination Survey, 2007–2012, we aimed to explore the relationship between total vitamin C intake and hypothyroidism in patients with HT, using multivariate logistic regression models and restricted cubic spline analyses. Our results showed a significant negative linear association between total vitamin C intake (log10-transformed data) and hypothyroidism in HT. Compared with those with the lowest quartile of total vitamin C intake (log10-transformed), participants with the highest quartile were at lower odds of having hypothyroidism (adjusted OR 0·40, 95 % CI: 0·18, 0·88, Ptrend = 0·027). This association was consistent in subgroups stratified by sex (Pfor interaction = 0·084) and age (≥ 60 years and < 60 years, Pfor interaction = 0·330). This study revealed that total vitamin C intake was inversely associated with hypothyroidism among individuals with HT, indicating that higher vitamin C intakes (4·57–1258·9 mg/d) may be associated with a lower likelihood of hypothyroidism among HT participants.

Keywords

Vitamin CDietaryAutoimmune thyroiditisHypothyroidismOxidative stress
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 12 , 28 December 2024 , pp. 1575 - 1583
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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