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Self-processing in relation to emotion and reward processing in depression

Published online by Cambridge University Press:  07 September 2021

Catherine Hobbs Open the ORCID record for Catherine Hobbs [Opens in a new window] ,
Jie Sui ,
David Kessler ,
Marcus R. Munafò  and
Katherine S. Button
Catherine Hobbs*
Affiliation:
Department of Psychology, University of Bath, Bath, UK
Jie Sui
Affiliation:
School of Psychology, University of Aberdeen, Aberdeen, UK
David Kessler
Affiliation:
Population Health Sciences, University of Bristol, Bristol, UK
Marcus R. Munafò
Affiliation:
School of Psychological Science, University of Bristol, Bristol, UK MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK National Institute of Health Research Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK
Katherine S. Button
Affiliation:
Department of Psychology, University of Bath, Bath, UK
*
Author for correspondence: Catherine Hobbs, E-mail: [email protected]
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Abstract

Background

Depression is characterised by a heightened self-focus, which is believed to be associated with differences in emotion and reward processing. However, the precise relationship between these cognitive domains is not well understood. We examined the role of self-reference in emotion and reward processing, separately and in combination, in relation to depression.

Methods

Adults experiencing varying levels of depression (n = 144) completed self-report depression measures (PHQ-9, BDI-II). We measured self, emotion and reward processing, separately and in combination, using three cognitive tasks.

Results

When self-processing was measured independently of emotion and reward, in a simple associative learning task, there was little association with depression. However, when self and emotion processing occurred in combination in a self-esteem go/no-go task, depression was associated with an increased positive other bias [b = 3.51, 95% confidence interval (CI) 1.24–5.79]. When the self was processed in relation to emotion and reward, in a social evaluation learning task, depression was associated with reduced positive self-biases (b = 0.11, 95% CI 0.05–0.17).

Conclusions

Depression was associated with enhanced positive implicit associations with others, and reduced positive learning about the self, culminating in reduced self-favouring biases. However, when self, emotion and reward processing occurred independently there was little evidence of an association with depression. Treatments targeting reduced positive self-biases may provide more sensitive targets for therapeutic intervention and potential biomarkers of treatment responses, allowing the development of more effective interventions.

Keywords

Depressionselfself-schemaemotionrewardaffective biases
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 5 , April 2023 , pp. 1924 - 1936
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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References

Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. American Journal of Psychiatry, 165(8), 969–977. https://doi.org/10.1176/appi.ajp.2008.08050721.CrossRefGoogle ScholarPubMed
Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for the Beck depression inventory-II. San Antonio, TX: Psychological Corporation.Google Scholar
Blakemore, S. J., & Mills, K. L. (2014). Is adolescence a sensitive period for sociocultural processing? Annual Review of Psychology, 65, 187–207. https://doi.org/10.1146/annurev-psych-010213-115202.CrossRefGoogle ScholarPubMed
Button, K. S., Browning, M., Munafò, M. R., & Lewis, G. (2012). Social inference and social anxiety: Evidence of a fear-congruent self-referential learning bias. Journal of Behavior Therapy and Experimental Psychiatry, 43(4), 1082–1087. https://doi.org/10.1016/j.jbtep.2012.05.004.CrossRefGoogle ScholarPubMed
Button, K. S., Karwatowska, L., Kounali, D., Munafò, M. R., & Attwood, A. S. (2016). Acute anxiety and social inference: An experimental manipulation with 7.5% carbon dioxide inhalation. Journal of Psychopharmacology, 30(10), 1036–1046. https://doi.org/10.1177/0269881116653105.CrossRefGoogle ScholarPubMed
Button, K. S., Kounali, D., Stapinski, L., Rapee, R. M., Lewis, G., & Munafò, M. R. (2015). Fear of negative evaluation biases social evaluation inference: Evidence from a probabilistic learning task. PLoS ONE, 10(4), e0119456. https://doi.org/10.1371/journal.pone.0119456.CrossRefGoogle ScholarPubMed
Cameron, I. M., Crawford, J. R., Lawton, K., & Reid, I. C. (2008). Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care. British Journal of General Practice, 58(546), 32–36. https://doi.org/10.3399/bjgp08X263794.CrossRefGoogle ScholarPubMed
Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., … Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. FOCUS, 16(4), 420–429. https://doi.org/10.1176/appi.focus.16407.CrossRefGoogle ScholarPubMed
Cuijpers, P., Andersson, G., Donker, T., & Van Straten, A. (2011). Psychological treatment of depression: Results of a series of meta-analyses. Nordic Journal of Psychiatry, 65(6), 354–364. https://doi.org/10.3109/08039488.2011.596570.CrossRefGoogle ScholarPubMed
Cunningham, S. J., & Turk, D. J. (2017). A review of self-processing biases in cognition. Quarterly Journal of Experimental Psychology, 70(6), 987–995. https://doi.org/10.1080/17470218.2016.1276609.CrossRefGoogle ScholarPubMed
Dalgleish, T., & Watts, F. N. (1990). Biases of attention and memory in disorders of anxiety and depression. Clinical Psychology Review, 10(5), 589–604. https://doi.org/10.1016/0272-7358(90)90098-U.CrossRefGoogle Scholar
Dalili, M. N., Penton-Voak, I. S., Harmer, C. J., & Munafò, M. R. (2015). Meta-analysis of emotion recognition deficits in major depressive disorder. Psychological Medicine, 45(6), 1135–1144. https://doi.org/10.1017/S0033291714002591.CrossRefGoogle ScholarPubMed
De Jong, P. J. (2002). Implicit self-esteem and social anxiety: Differential self-favouring effects in high and low anxious individuals. Behaviour Research and Therapy, 40(5), 501–508. https://doi.org/10.1016/S0005-7967(01)00022-5.CrossRefGoogle ScholarPubMed
De Jong, P. J., Sportel, B. E., De Hullu, E., & Nauta, M. H. (2012). Co-occurrence of social anxiety and depression symptoms in adolescence: Differential links with implicit and explicit self-esteem? Psychological Medicine, 42(3), 475. https://doi.org/10.1017/S0033291711001358.CrossRefGoogle ScholarPubMed
Eshel, N., & Roiser, J. P. (2010). Reward and punishment processing in depression. Biological Psychiatry, 68(2), 118–124. https://doi.org/10.1016/j.biopsych.2010.01.027.CrossRefGoogle ScholarPubMed
Franck, E., De Raedt, R., & De Houwer, J. (2008). Activation of latent self-schemas as a cognitive vulnerability factor for depression: The potential role of implicit self-esteem. Cognition and Emotion, 22(8), 1588–1599. https://doi.org/10.1080/02699930801921271.CrossRefGoogle Scholar
Gaddy, M. A., & Ingram, R. E. (2014). A meta-analytic review of mood-congruent implicit memory in depressed mood. Clinical Psychology Review, 34(5), 402–416. https://doi.org/10.1016/j.cpr.2014.06.001.CrossRefGoogle ScholarPubMed
Gregg, A. P., & Sedikides, C. (2010). Narcissistic fragility: Rethinking its links to explicit and implicit self-esteem. Self and Identity, 9(2), 142–161. https://doi.org/10.1080/15298860902815451.CrossRefGoogle Scholar
Hahn, A., Judd, C. M., Hirsh, H. K., & Blair, I. V. (2014). Awareness of implicit attitudes. Journal of Experimental Psychology: General, 143(3), 1369–1392. https://doi.org/10.1037/a0035028.CrossRefGoogle ScholarPubMed
Hertel, P. T., & El-Messidi, L. (2006). Am I blue? Depressed mood and the consequences of self-focus for the interpretation and recall of ambiguous words. Behavior Therapy, 37(3), 259–268. https://doi.org/10.1016/j.beth.2006.01.003.CrossRefGoogle Scholar
Higgins, E. T. (1987). Self-discrepancy: A theory relating self and affect. Psychological Review, 94(3), 319. https://doi.org/10.1037/0033-295X.94.3.319.CrossRefGoogle ScholarPubMed
Hirschfeld, R., Montgomery, S., Keller, M., Kasper, S., Schatzberg, A., Moller, H.-J., … Bourgeois, M. (2000). Social functioning in depression: A review. Journal of Clinical Psychiatry, 61(4), 268–275.CrossRefGoogle ScholarPubMed
Hobbs, C., Faraway, J., Kessler, D., Munafò, M. R., Sui, J., & Button, K. S. (2019). Social evaluation learning in social anxiety disorder and depression: A mega-analysis presented at the summer meeting of the British Association for Psychopharmacology . Journal of Psychopharmacology, Supplement, 33(8), A33.Google Scholar
Hobbs, C., Sui, J., Kessler, D., Munafò, M. R., & Button, K. S. (2020). Dataset for ‘Self processing in relation to emotion and reward processing in depression. Bath, UK: University of Bath Research Data. https://doi.org/https://doi.org/10.15125/BATH-00924..Google Scholar
Hsu, K. J., McNamara, M. E., Shumake, J., Stewart, R. A., Labrada, J., Alario, A., … Beevers, C. G. (2020). Neurocognitive predictors of self-reported reward responsivity and approach motivation in depression: A data-driven approach. Depression and Anxiety, 37, 682–697. https://doi.org/10.1002/da.23042.CrossRefGoogle ScholarPubMed
Ji, J. L., Grafton, B., & MacLeod, C. (2017). Referential focus moderates depression-linked attentional avoidance of positive information. Behaviour Research and Therapy, 93, 47–54. https://doi.org/10.1016/j.brat.2017.03.004.CrossRefGoogle ScholarPubMed
Kendrick, T., Dowrick, C., McBride, A., Howe, A., Clarke, P., Maisey, S., … Smith, P. W. (2009). Management of depression in UK general practice in relation to scores on depression severity questionnaires: Analysis of medical record data. BMJ (Online), 338(7697), b750. https://doi.org/10.1136/bmj.b750.CrossRefGoogle ScholarPubMed
Korn, C. W., Prehn, K., Park, S. Q., Walter, H., & Heekeren, H. R. (2012). Positively biased processing of self-relevant social feedback. Journal of Neuroscience, 32(47), 16832–16844. https://doi.org/10.1523/JNEUROSCI.3016-12.2012.CrossRefGoogle ScholarPubMed
Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606–613.CrossRefGoogle ScholarPubMed
Kuiper, N. A., Derry, P. A., & MacDonald, M. R. (1982). Self-reference and person perception in depression: A social cognition perspective. In Weary, G., Mirels, H. L., & Mirels, H. (Eds.), Integrations of clinical and social psychology (pp. 79–2103). Oxford, UK: Oxford University Press.Google Scholar
Leary, M. R. (1983). A brief version of the fear of negative evaluation scale. Personality and Social Psychology Bulletin, 9(3), 371–375. https://doi.org/10.1177/0146167283093007.CrossRefGoogle Scholar
Lewinsohn, P. M., Mischel, W., Chaplin, W., & Barton, R. (1980). Social competence and depression: The role of illusory self-perceptions. Journal of Abnormal Psychology, 89(2), 203. https://doi.org/10.1037/0021-843X.89.2.203.CrossRefGoogle ScholarPubMed
Lewis, G., Button, K. S., Pearson, R. M., Munafò, M. R., & Lewis, G. (2020). Inhibitory control of positive and negative information and adolescent depressive symptoms: A population-based cohort study. Psychological Medicine, 1–11. https://doi.org/https://doi.org/10.1017/S0033291720002469.Google ScholarPubMed
Lewis, G., Pelosi, A., Araya, R., & Dunn, G. (1992). Measuring psychiatric disorder in the community: A standardized assessment for use by lay interviewers. Psychological Medicine, 22(2), 465–486. https://doi.org/10.1017/S0033291700030415.CrossRefGoogle ScholarPubMed
Ma, Y., & Han, S. (2010). Why we respond faster to the self than to others? An implicit positive association theory of self-advantage during implicit face recognition. Journal of Experimental Psychology: Human Perception and Performance, 36(3), 619–633. https://doi.org/10.1037/a0015797.Google Scholar
Maslej, M. M., Furukawa, T. A., Cipriani, A., Andrews, P. W., & Mulsant, B. H. (2020). Individual differences in response to antidepressants: A meta-analysis of placebo-controlled randomized clinical trials. JAMA Psychiatry, 77(6), 607–617. https://doi.org/10.1001/jamapsychiatry.2019.4815.CrossRefGoogle ScholarPubMed
Northoff, G. (2007). Psychopathology and pathophysiology of the self in depression – neuropsychiatric hypothesis. Journal of Affective Disorders, 104(1–3), 1–14. https://doi.org/10.1016/j.jad.2007.02.012.CrossRefGoogle ScholarPubMed
Northoff, G., & Hayes, D. J. (2011). Is our self-nothing but reward? Biological Psychiatry, 69(11), 1019–1025. https://doi.org/10.1016/j.biopsych.2010.12.014.CrossRefGoogle ScholarPubMed
Parsons, S., Kruijt, A.-W., & Fox, E. (2019). Psychological science needs a standard practice of reporting the reliability of cognitive-behavioral measurements. Advances in Methods and Practices in Psychological Science, 2(4), 378–395. https://doi.org/10.1177/2515245919879695.CrossRefGoogle Scholar
Rosenberg, M.. (1965). Society and the adolescent self-image. Princeton, New Jersey, USA: Princeton University Press.CrossRefGoogle Scholar
Royal College of Psychiatrists (2011). Mental health of students in higher education. London, UK: Royal College of Psychiatrists. https://www.rcpsych.ac.uk/docs/default-source/improving-care/better-mh-policy/college-reports/college-report-cr166.pdf?sfvrsn=d5fa2c24_2.Google Scholar
Sheline, Y. I., Barch, D. M., Price, J. L., Rundle, M. M., Vaishnavi, S. N., Snyder, A. Z., … Raichle, M. E. (2009). The default mode network and self-referential processes in depression. Proceedings of the National Academy of Sciences of the United States of America, 106(6), 1942–1947. https://doi.org/10.1073/pnas.0812686106.CrossRefGoogle ScholarPubMed
Simon, G. E., & Perlis, R. H. (2010). Personalized medicine for depression: Can we match patients with treatments? American Journal of Psychiatry, 167(12), 1445–1455. https://doi.org/10.1176/appi.ajp.2010.09111680.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder. Archives of Internal Medicine, 166(10), 1092–1097. https://doi.org/10.1001/archinte.166.10.1092.CrossRefGoogle ScholarPubMed
Stolte, M., Humphreys, G., Yankouskaya, A., & Sui, J. (2017). Dissociating biases towards the self and positive emotion. Quarterly Journal of Experimental Psychology, 70(6), 1011–1022. https://doi.org/10.1080/17470218.2015.1101477.CrossRefGoogle ScholarPubMed
Sui, J., & Button, K. S. (2017). Associative learning and depression. Unpublished Data.Google Scholar
Sui, J., He, X., & Humphreys, G. W. (2012). Perceptual effects of social salience: Evidence from self-prioritization effects on perceptual matching. Journal of Experimental Psychology: Human Perception and Performance, 38(5), 1105. https://doi.org/10.1037/a0029792.Google ScholarPubMed
Sui, J., & Humphreys, G. W. (2015a). The integrative self: How self-reference integrates perception and memory. Trends in Cognitive Sciences, 19(12), 719–728. https://doi.org/10.1016/j.tics.2015.08.015.CrossRefGoogle ScholarPubMed
Sui, J., & Humphreys, G. W. (2015b). The interaction between self-bias and reward: Evidence for common and distinct processes. Quarterly Journal of Experimental Psychology, 68(10), 1952–1964. https://doi.org/10.1080/17470218.2015.1023207.CrossRefGoogle ScholarPubMed
Sui, J., Ohrling, E., & Humphreys, G. W. (2016). Negative mood disrupts self- and reward-biases in perceptual matching. Quarterly Journal of Experimental Psychology, 69(7), 1438–1448. https://doi.org/10.1080/17470218.2015.1122069.CrossRefGoogle ScholarPubMed
Takano, K., Van Grieken, J., & Raes, F. (2019). Difficulty in updating positive beliefs about negative cognition is associated with increased depressed mood. Journal of Behavior Therapy and Experimental Psychiatry, 64, 22–30. https://doi.org/10.1016/j.jbtep.2019.02.001.CrossRefGoogle ScholarPubMed
Teo, A. R., Choi, H. J., & Valenstein, M. (2013). Social relationships and depression: Ten-year follow-up from a nationally representative study. PLoS ONE, 8(4), e62396. https://doi.org/10.1371/journal.pone.0062396.CrossRefGoogle ScholarPubMed
Tomitaka, S., Kawasaki, Y., & Furukawa, T. (2015). A distribution model of the responses to each depressive symptom item in a general population: A cross-sectional study. BMJ Open, 5(9), e008599. https://doi.org/10.1136/bmjopen-2015-008599.CrossRefGoogle Scholar
Uher, R., Mors, O., Rietschel, M., Rajewska-Rager, A., Petrovic, A., Zobel, A., … McGuffin, P. (2011). Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression. The Journal of Clinical Psychiatry, 72(11), 1586–1592. https://doi.org/10.4088/jcp.10m06419.CrossRefGoogle ScholarPubMed
Van Tuijl, L. A., De Jong, P. J., Sportel, B. E., De Hullu, E., & Nauta, M. H. (2014). Implicit and explicit self-esteem and their reciprocal relationship with symptoms of depression and social anxiety: A longitudinal study in adolescents. Journal of Behavior Therapy and Experimental Psychiatry, 45(1), 113–121. https://doi.org/10.1016/j.jbtep.2013.09.007.CrossRefGoogle ScholarPubMed
Wang, Y. P., & Gorenstein, C. (2013). Psychometric properties of the beck depression inventory-II: A comprehensive review. Brazilian Journal of Psychiatry, 35(4), 416–431. https://doi.org/10.1590/1516-4446-2012-1048.CrossRefGoogle ScholarPubMed
Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063. https://doi.org/10.1037//0022-3514.54.6.1063.CrossRefGoogle ScholarPubMed
Weeks, J. W., Heimberg, R. G., & Rodebaugh, T. L. (2008). The fear of positive evaluation scale: Assessing a proposed cognitive component of social anxiety. Journal of Anxiety Disorders, 22(1), 44–55. https://doi.org/10.1016/j.janxdis.2007.08.002.CrossRefGoogle ScholarPubMed
Weissman, A. N., & Beck, A. T. (1978). Development and validation of the dysfunctional attitude scale: A preliminary investigation. Acceptance and Commitment Therapy, 54, 1–22.Google Scholar
Williams, B. J., & Kaufmann, L. M. (2012). Reliability of the Go/No Go association task. Journal of Experimental Social Psychology, 48(4), 879–891. https://doi.org/10.1016/j.jesp.2012.03.001.CrossRefGoogle Scholar
World Health Organization (2011). Global burden of mental disorders and the need for a comprehensive, coordinated response from health and social sectors at the country level. EB130/9. https://doi.org/https://apps.who.int/gb/ebwha/pdf_files/eb130/b130_9-en.pdf.Google Scholar
World Health Organization (2017). Depression and Other Common Mental Disorders: Global Health Estimates. No. WHO/MSD/MER/2017.2. https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf.Google Scholar
Zell, E., Strickhouser, J. E., Sedikides, C., & Alicke, M. D. (2019). The better-than-average effect in comparative self- evaluation: A comprehensive review and meta-analysis. Psychological Bulletin, 146(2), 118. https://doi.org/10.1037/bul0000218.CrossRefGoogle ScholarPubMed
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