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Comparison of weight loss induced by dietary and pharmaceuticals in individuals with overweight and obesity: a retrospective study

Published online by Cambridge University Press:  14 November 2024

Lei-lei Wang Open the ORCID record for Lei-lei Wang [Opens in a new window] ,
Ling-ling Wang ,
Xiao-chen Liu ,
Hai-ying Hu ,
Hong-xia Li ,
Wei Wei ,
Qin Du  and
Hui-hui Yan
Lei-lei Wang
Affiliation:
Department of Clinical Nutrition, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Ling-ling Wang
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Xiao-chen Liu
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Hai-ying Hu
Affiliation:
Department of Clinical Nutrition, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Hong-xia Li
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Wei Wei
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Qin Du*
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
Hui-hui Yan*
Affiliation:
Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310009, People’s Republic of China
*
Corresponding authors: Hui-hui Yan; Email: [email protected]; Qin Du; Email: [email protected]
Corresponding authors: Hui-hui Yan; Email: [email protected]; Qin Du; Email: [email protected]
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Abstract

This study aims to evaluate the impact of low-carbohydrate diet, balanced dietary guidance and pharmacotherapy on weight loss among individuals with overweight or obesity over a period of 3 months. The study involves 339 individuals with overweight or obesity and received weight loss treatment at the Department of Clinical Nutrition at the Second Affiliated Hospital of Zhejiang University, School of Medicine, between 1 January 2020 and 31 December 2023. The primary outcome is the percentage weight loss. Among the studied patients, the majority chose low-carbohydrate diet as their primary treatment (168 (49·56 %)), followed by balanced dietary guidance (139 (41·00 %)) and pharmacotherapy (32 (9·44 %)). The total percentage weight loss for patients who were followed up for 1 month, 2 months and 3 months was 4·98 (3·04, 6·29) %, 7·93 (5·42, 7·93) % and 10·71 (7·74, 13·83) %, respectively. Multivariable logistic regression analysis identified low-carbohydrate diet as an independent factor associated with percentage weight loss of ≥ 3 % and ≥ 5 % at 1 month (OR = 0·461, P < 0·05; OR = 0·349, P < 0·001). The results showed that a low-carbohydrate diet was an effective weight loss strategy in the short term. However, its long-term effects were comparable to those observed with balanced dietary guidance and pharmacotherapy.

Keywords

OverweightObesityLow-carbohydrate dietBalanced dietary guidancePharmacotherapy
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 12 , 28 December 2024 , pp. 1611 - 1620
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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