Pousa et al comment that our conclusion that theory of mind impairment represents a possible trait marker for schizophrenia should remain tentative for two reasons. Regarding their first argument, data on remitted patients are indeed limited and have methodological shortcomings. Only five studies in remitted patients were available, and the number of remitted patients in each of these studies was small. We also remarked that the criteria for remission used may have varied across studies, and that other factors may have influenced the results. Thus, we agree that the conclusion that theory of mind impairment represents a trait marker for schizophrenia should be tentative. In fact, we did describe it as a ‘possible’ trait marker. It is important to note that meta-analyses are about effect sizes rather than significance levels. By synthesising data of multiple studies there is more statistical power to detect smaller group differences. Thus, although in three out of five studies the theory of mind impairment in remitted patients was not statistically significant, when the studies were combined, the overall effect was significant (mean d=–0.692, P<0.01). So when Pousa et al do no find theory of mind impairment in stable remitted patients, we are not only interested in the P-levels, but also in the effect size. We also agree with the second point that there is evidence of an association between psychotic symptoms and theory of mind impairment, but do not see why this would argue against our conclusion. Frith Reference Frith1 already proposed associations between specific schizophrenia symptoms (e.g. paranoid delusions) and mentalising impairment, and in their upcoming paper Pousa et al apparently also find significant associations between theory of mind impairment and psychotic symptoms. Perhaps we should have stated that theory of mind impairment is a possible trait marker for psychosis rather than schizophrenia. We believe that theory of mind probably does not represent an ‘all or nothing’ skill, and that schizophrenia should perhaps be studied using a dimensional instead of a categorical approach.
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