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Higher left ventricular stroke volume is associated with aortic dilatation in repaired tetralogy of Fallot patients

Published online by Cambridge University Press:  23 October 2024

Yuki Kawasaki Open the ORCID record for Yuki Kawasaki [Opens in a new window] ,
Daiji Takajo Open the ORCID record for Daiji Takajo [Opens in a new window] ,
Pooja Gupta  and
Sanjeev Aggarwal
Yuki Kawasaki
Affiliation:
Department of Pediatric Cardiology, Osaka City General Hospital Pediatric Medical Center, Osaka, Japan Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
Daiji Takajo*
Affiliation:
Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Pooja Gupta
Affiliation:
Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
Sanjeev Aggarwal
Affiliation:
Division of Cardiology, Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
*
Corresponding author: Daiji Takajo; Email: [email protected]
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Abstract

Aortic root dilation has been reported commonly after repair of tetralogy of Fallot. However, the rate and risk factors of progression of the dilation are not fully understood. This is a single-centre, retrospective study to assess the rate and factors associated with progressive dilatation of the aortic root in repaired tetralogy of Fallot patients using cardiac MRI. The presence of the significant aortic dilation and the progression of dilation between initial and follow-up cardiac MRI were examined. The study cohort comprised 72 patients with repaired tetralogy of Fallot. The median age at the initial cardiac MRI scan was 19.6 (interquartile range: 14.6–31) years, and the median follow-up interval was 4.3 (2.9–5.7) years. Median dimension of ascending aorta at initial and follow-up cardiac MRI was 27.0 (22.3–31.0) mm and 29.2 (25.0–32.1) mm, respectively. Significant aortic dilation (the percentage predicted ascending aorta ≥150%) was observed in 11 (15.2%) patients at the initial cardiac MRI and 24 (33.3%) at the follow-up cardiac MRI. The significant aortic dilation at follow-up cardiac MRI was associated with increased indexed left ventricular stroke volume (odds ratio 1.062, p = 0.023). Thirteen patients demonstrated the significant progressive dilation of aorta between initial and follow-up cardiac MRI. The progressive dilation was associated with left ventricular ejection fraction at initial cardiac MRI (odds ratio 1.135, p = 0.048). In patients with repaired tetralogy of Fallot, aortic dilation is common and progresses over time. Cardiac MRI is a valuable tool for identifying individuals at risk for progressive aortic dilation.

Keywords

Tetralogy of Fallotaortic dilationleft ventricular stroke volumecardiac MRI
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 11 , November 2024 , pp. 2290 - 2295
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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