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Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold

Published online by Cambridge University Press:  20 July 2023

E Amini Open the ORCID record for E Amini [Opens in a new window] ,
M Rohani ,
S A H Habibi ,
Z Azad ,
N Yazdi ,
E Cubo ,
T Hummel  and
M Jalessi Open the ORCID record for M Jalessi [Opens in a new window]
E Amini
Affiliation:
ENT and Head and Neck Research Center, The Five Senses Health Institute, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
M Rohani
Affiliation:
Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Skull Base Research Center, The Five Senses Health Institute, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
S A H Habibi
Affiliation:
Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Z Azad
Affiliation:
Skull Base Research Center, The Five Senses Health Institute, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
N Yazdi
Affiliation:
Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
E Cubo
Affiliation:
Neurology Department, Hospital Universitario Burgos, University of Burgos, Burgos, Spain
T Hummel
Affiliation:
Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
M Jalessi*
Affiliation:
Skull Base Research Center, The Five Senses Health Institute, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Department of Otorhinolaryngology, Head and Neck Surgery, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
*
Corresponding author: Maryam Jalessi; Email: [email protected]
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Abstract

Background

Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.

Method

Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin’ Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients’ motor function was assessed based on the Unified Huntington's Disease Rating Scale.

Results

Compared with controls, patients’ scores of all olfactory domains and their sum were significantly lower. Besides, our patients’ odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent vs 34 per cent, respectively).

Conclusion

Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.

Keywords

Huntington's diseaseneurodegenerative diseasesolfaction disorderssmell
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 3 , March 2024 , pp. 315 - 320
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Maryam Jalessi takes responsibility for the integrity of the content of the paper

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