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Correlation of n-terminal pro-brain-type natriuretic peptide levels with the severity of single mitral regurgitation or accompanied by mild aorta valve dysfunction in patients with rheumatic heart disease in Sanglah general hospital

Published online by Cambridge University Press:  13 October 2023

Ricky Saunders Open the ORCID record for Ricky Saunders [Opens in a new window] ,
Eka Gunawijaya ,
I Nyoman Budi Hartawan ,
I Gusti Ngurah Sanjaya Putra ,
Anak Agung Ngurah Ketut Putra Widnyana  and
Made Sukmawati
Ricky Saunders*
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Eka Gunawijaya
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Nyoman Budi Hartawan
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Gusti Ngurah Sanjaya Putra
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Anak Agung Ngurah Ketut Putra Widnyana
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Made Sukmawati
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
*
Corresponding author: R. Saunders; Email: saunders250792@gmail.com
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Abstract

Background:

The most frequent abnormality of the valves involved in rheumatic heart disease is mitral regurgitation. A promising supportive diagnostic tool for rheumatic heart disease is the N-terminal pro-brain natriuretic peptide, which can identify mitral valve damage.

Objective:

To prove a positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation or accompanied by mild aortic valve dysfunction in children with rheumatic heart disease.

Material and method:

Children aged 1–18 years who had been identified as having rheumatic heart disease with a single mitral regurgitation or accompanied by mild aortic issues at Sanglah General Hospital, Denpasar, met the inclusion criteria for this cross-sectional study. Mitral regurgitation severity was determined using the parameters of vena contracta width, effective regurgitation orifice area, regurgitant jet area, and regurgitation volume. Bivariate analysis using the Spearman correlation test.

Results:

From 36 research subjects, the mean age was 11.32 years. In this study, there was a moderate positive correlation between the levels of N-terminal pro-brain natriuretic peptide and the regurgitation jet area. N-terminal pro-brain natriuretic peptide levels also had a moderately positive correlation with the vena contracta width and a weakly positive correlation with the regurgitation volume. Effective regurgitation orifice area and N-terminal pro-brain natriuretic peptide levels did not significantly correlate.

Conclusion:

There was a moderately positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation on regurgitation jet area, a moderately positive correlation with the vena contracta width, and a weakly positive correlation with regurgitation volume in rheumatic heart disease patients.

Keywords

Mitral regurgitationrheumatic heart diseaseN-terminal pro -brain natriuretic peptide
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 4 , April 2024 , pp. 788 - 792
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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