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Correlation of n-terminal pro-brain-type natriuretic peptide levels with the severity of single mitral regurgitation or accompanied by mild aorta valve dysfunction in patients with rheumatic heart disease in Sanglah general hospital

Published online by Cambridge University Press:  13 October 2023

Ricky Saunders Open the ORCID record for Ricky Saunders [Opens in a new window] ,
Eka Gunawijaya ,
I Nyoman Budi Hartawan ,
I Gusti Ngurah Sanjaya Putra ,
Anak Agung Ngurah Ketut Putra Widnyana  and
Made Sukmawati
Ricky Saunders*
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Eka Gunawijaya
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Nyoman Budi Hartawan
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
I Gusti Ngurah Sanjaya Putra
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Anak Agung Ngurah Ketut Putra Widnyana
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
Made Sukmawati
Affiliation:
Department of Child Health, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia
*
Corresponding author: R. Saunders; Email: [email protected]
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Abstract

Background:

The most frequent abnormality of the valves involved in rheumatic heart disease is mitral regurgitation. A promising supportive diagnostic tool for rheumatic heart disease is the N-terminal pro-brain natriuretic peptide, which can identify mitral valve damage.

Objective:

To prove a positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation or accompanied by mild aortic valve dysfunction in children with rheumatic heart disease.

Material and method:

Children aged 1–18 years who had been identified as having rheumatic heart disease with a single mitral regurgitation or accompanied by mild aortic issues at Sanglah General Hospital, Denpasar, met the inclusion criteria for this cross-sectional study. Mitral regurgitation severity was determined using the parameters of vena contracta width, effective regurgitation orifice area, regurgitant jet area, and regurgitation volume. Bivariate analysis using the Spearman correlation test.

Results:

From 36 research subjects, the mean age was 11.32 years. In this study, there was a moderate positive correlation between the levels of N-terminal pro-brain natriuretic peptide and the regurgitation jet area. N-terminal pro-brain natriuretic peptide levels also had a moderately positive correlation with the vena contracta width and a weakly positive correlation with the regurgitation volume. Effective regurgitation orifice area and N-terminal pro-brain natriuretic peptide levels did not significantly correlate.

Conclusion:

There was a moderately positive correlation between N-terminal pro-brain natriuretic peptide levels and the severity of mitral regurgitation on regurgitation jet area, a moderately positive correlation with the vena contracta width, and a weakly positive correlation with regurgitation volume in rheumatic heart disease patients.

Keywords

Mitral regurgitationrheumatic heart diseaseN-terminal pro -brain natriuretic peptide
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 4 , April 2024 , pp. 788 - 792
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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References

Bernstein, D. Rheumatic heart disease. In Nelson Textbook of Pediatrics, 20th (edn). Elsevier, Philadelphia, 2016: 2269–2270.Google Scholar
Hasnul, M, Najirman, Y. Karakteristik pasien penyakit jantung rematik yang dirawat inap di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas 2015; 4: 894–900.CrossRefGoogle Scholar
Laudari, S, Subramanyam, G. A study of spectrum of rheumatic heart disease in a tertiary care hospital in central Nepal. IJC Heart Vasc 2017; 15: 26–30.10.1016/j.ijcha.2017.03.007CrossRefGoogle Scholar
Gardezi, SKM, Coffey, S, Prendergast, BD, Myerson, SG. Serum biomarkers in valvular heart disease. Heart 2018; 104: 349–358.CrossRefGoogle ScholarPubMed
Fernandes, BA, Maher, KO, Deshpande, SR. Cardiac biomarkers in pediatric heart disease: a state of art review. World J Cardiol 2016; 8: 719–727.CrossRefGoogle ScholarPubMed
Chopra, S, Cherian, D, Verghese, PP, Jacob, JJ. Physiology and clinical significance of natriuretic hormones. Indian J Endocrinol Metab 2013; 17: 83–90.Google ScholarPubMed
Petracca, F, Affuso, F, Pasquale, DC, et al. Usefulness of NT-proBNP in the assessment of patients with aortic or mitral regugirtation. J Cardiovasc Med 2009; 10: 929–932.CrossRefGoogle ScholarPubMed
Zhang, J, Wang, X, Xiao, W, et al. NT-proBNP is associated with age, gender, and glomerular filtration rate in a community-dwelling population. Int J Clin Exp Med 2019; 12: 12220–12227.Google Scholar
Hall, C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail 2004; 6: 257–260.CrossRefGoogle ScholarPubMed
Steadman, CD, Ray, S, L., L, McCann, GP. Natriuretic peptides in common valvular heart disease. J Am Coll Cardiol 2010; 55: 2034–2048.CrossRefGoogle ScholarPubMed
Hall, C. NT-proBNP : the mechanisme behind the marker. J Card Fail 2005; 11: S82–2.CrossRefGoogle Scholar
Lilyasari, O, Prakoso, R, Kurniawati, Y, et al. Clinical profile and management of rheumatic heart disease in children and young adults at a tertiary cardiac center in Indonesia. Front Surg 2020; 7: 1–9.CrossRefGoogle Scholar
Tobing, TCL, Ontoseno, T, Rahayuningsih, S, Ganie, RA, Siregar, Y. Relationship between environmental factors and rheumatic heart disease. Maced J Med Sci 2021; 19: 1795–1798.CrossRefGoogle Scholar
Lubega, S, Aliku, T, Lwabi, P. Echocardiographic pattern and severity of valve dysfunction in children with rheumatic heart disease seen at Uganda heart institute, Mulago hospital. Afr Health Sci 2014; 14: 617–625.CrossRefGoogle ScholarPubMed
Erolu, E, Akalin, F. Mitral regurgitation and serum N-terminal pro-brain natriuretic peptide levels in children: a modification of adult criteria. Tex Heart Inst J 2022; 49: 1–8.Google ScholarPubMed
Grayburn, PA, Weissman, NJ, Zamorano, JL. Quantitation of mitral regurgitation. Circulation 2012; 126: 2005–2017.CrossRefGoogle ScholarPubMed
Nugroho, FW, Rohman, MS, Rizal, A, Martini, H, Prasetya, I, Makhmud, T. Profile of pediatric rheumatic heart disease patients with mitral regurgitation receiving angiotensin-converting enzyme inhibitor in dr. Saiful Anwar general hospital Malang. Heart Sci J 2021; 2: 9–14.CrossRefGoogle Scholar
Mehta, A, Saxena, A, Juneja, R, Ramakrishnan, S, Gupta, S, Kothari, SS. Characteristics and outcomes of Indian children enrolled in a rheumatic heart disease registry. Int JCardiol 2016; 1: 1136–1140.CrossRefGoogle Scholar
Gaasch, WH, Meyer, TE. Left ventricular response to mitral regurgitation: implications for management. Circulation 2008; 118: 2298–2303.10.1161/CIRCULATIONAHA.107.755942CrossRefGoogle ScholarPubMed
Yeong, M, Silbery, M, Finucane, K, Wilson, NJ, Gentles, TL. Mitral valve geometry in paediatric rheumatic mitral regurgitation. Pediatr Cardiol 2015; 36: 827–834.10.1007/s00246-014-1085-1CrossRefGoogle ScholarPubMed