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Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis

Published online by Cambridge University Press:  02 January 2018

Oliver D. Howes ,
Andrew J. Montgomery ,
Marie-Claude Asselin ,
Robin M. Murray ,
Paul M. Grasby  and
Philip K. Mcguire
Oliver D. Howes*
Affiliation:
Institute of Psychiatry, Camberwell, London, UK
Andrew J. Montgomery
Affiliation:
Clinical Sciences Centre, Hammersmith Hospital, London, UK
Marie-Claude Asselin
Affiliation:
Hammersmith Imanet, Hammersmith Hospital, London, UK
Robin M. Murray
Affiliation:
Institute of Psychiatry, London, UK
Paul M. Grasby
Affiliation:
Clinical Sciences Centre, Hammersmith Hospital, London, UK
Philip K. Mcguire
Affiliation:
Institute of Psychiatry, London, UK
*
Oliver D. Howes, Institute of Psychiatry, Camberwell, London SE5 8AF, UK. Email: [email protected]
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Summary

The dopamine hypothesis has been the major pathophysiological theory of psychosis in recent decades. Molecular imaging studies have provided in vivo evidence of increased dopamine synaptic availability and increased presynaptic dopamine synthesis in the striata of people with psychotic illnesses. These studies support the predictions of the dopamine hypothesis, but it remains to be determined whether dopaminergic abnormalities pre-date or are secondary to the development of psychosis. We selectively review the molecular imaging studies of the striatal dopaminergic system in psychosis and link this to models of psychosis and the functional subdivisions of the striatum to make predictions for the dopaminergic system in the prodromal phase of psychosis

Type
Editorials
Information
The British Journal of Psychiatry , Volume 191 , Issue S51: Early phase of psychosis , December 2007 , pp. s13 - s18
Copyright
Copyright © Royal College of Psychiatrists, 2007 

THE DOPAMINE HYPOTHESIS OF PSYCHOSIS

The predominant pathophysiological theory of psychosis postulates that dopamine dysfunction is the final common pathway driving its development (Reference Carlsson and LindqvistCarlsson & Lindqvist, 1963; Reference Davis, Kahn and KoDavis et al, 1991; Reference KapurKapur, 2003). It is hypothesised that hyperactivity of the dopamine system leads to the psychotic symptoms seen in conditions such as schizophrenia (Reference KapurKapur, 2003). Recent elaborations of this model propose that striatal hyperdopaminergia results in aberrant salience being attached to what would normally be innocuous stimuli that then form the basis of the hallucinations and delusions of psychosis (Reference KapurKapur, 2003). Additionally it has been proposed that there is an interaction between striatal dopamine overactivity and frontal dopamine hypoactivity, with the latter associated with some of the neurocognitive deficits seen in schizophrenia (Reference WillnerWillner, 1997; Reference Laruelle, Kegeles and Abi-DarghamLaruelle et al, 2003; Reference Abi-DarghamAbi-Dargham, 2004;). This is supported by a mouse model in which dopamine D2 receptor overexpression in the striatum is associated with selective working memory deficits, and decreased dopamine turnover and D1 receptor activation in the frontal cortex (Reference Kellendonk, Simpson and PolanKellendonk et al, 2006).

There is considerable indirect or ex vivo evidence of dopamine dysfunction in psychosis based on studies of dopaminergic agonists, antagonists, and post-mortem studies reviewed by Carlsson and colleagues (Reference Carlsson, Hansson and WatersCarlsson et al, 1997). Pharmacological studies show a correlation between clinical doses of antipsychotic drugs and their potency for blocking D2 receptors, and provide further evidence for the involvement of dopamine in psychosis through the psychotogenic effects of dopamine enhancing drugs (Reference Seeman and LeeSeeman & Lee, 1975; Reference Meltzer and StahlMeltzer & Stahl, 1976; Reference HaraczHaracz, 1982; Reference Lieberman, Kane and AlvirLieberman et al, 1987). These studies strongly suggest, but do not establish, the existence of a dysregulation of dopamine transmission in psychosis. Post-mortem findings of chronic psychotic conditions have been mixed. Although direct tissue measures of dopamine and D2 receptor levels have been found to be elevated in the striatum, this has not been consistent, and post-mortem studies are confounded by antipsychotic exposure (Reference Kleinman, Casanova and JaskiwKleinman et al, 1988; Reference ReynoldsReynolds, 1989; Reference Davis, Kahn and KoDavis et al, 1991; Reference Zakzanis and HansenZakzanis & Hansen, 1998).

IN VIVO MOLECULAR IMAGING OF STRIATAL DOPAMINERGIC SYSTEMS

Studies of dopamine receptors and dopamine release

Developments in human molecular imaging over the past 20 years have allowed aspects of dopaminergic function to be examined in vivo. The early studies in psychosis, predominantly schizophrenia, examined the striatal postsynaptic dopamine D2 receptor density using positron emission tomography (PET) and single photon emission computed tomography (SPECT) tracers including various radiolabelled analogues of spiperone, [11C]raclopride and [123I]IBZM. The findings of these studies are inconsistent, with some reporting increased D2 receptor binding in schizophrenia (Reference Crawley, Crow and JohnstoneCrawley et al, 1986; Reference Wong, Wagner and TuneWong et al, 1986; Reference Gjedde and WongGjedde & Wong, 1987) and others no difference from controls (Reference Farde, Wiesel and Stone-ElanderFarde et al, 1990; Reference Martinot, Peron-Magnan and HuretMartinot et al, 1990). However a meta-analysis of these studies concluded that there is a modest elevation in the D2 receptor densities in people with psychotic illnesses, with an effect size of approximately 0.5 (Reference LaruelleLaruelle, 1998). The two studies that have investigated D1 receptor densities in the striatum of patients with psychotic illnesses report no difference from controls, indicating that striatal D1 receptor levels are unchanged in psychosis, although there may be differences in other brain regions (Reference Okubo, Suhara and SuzukiOkubo et al, 1997; Reference Karlsson, Farde and HalldinKarlsson et al, 2002).

Other studies have examined the striatal synaptic availability and release of dopamine (Laruelle et al, Reference Laruelle, Abi-Dargham and van Dyck1996, Reference Laruelle, Abi-Dargham and Gil1999; Reference Breier, Su and SaundersBreier et al, 1997; Abi-Dargham et al, Reference Abi-Dargham, Gil and Krystal1998, Reference Abi-Dargham, Rodenhiser and Printz2000) by employing radiotracers whose binding is sensitive to endogenous dopamine levels such as [11C]raclopride and [123I]IBZM. These studies have used amphetamine to probe the responsivity of the striatal dopaminergic system. Amphetamine acts to stimulate dopamine release from vesicles and reverse the dopamine transporter, increasing extracellular levels of dopamine (Reference Sulzer, Maidment and RayportSulzer et al, 1993; Reference Jones, Gainetdinov and WightmanJones et al, 1998). The competition model predicts that dopamine competes for binding to the D2 receptors with the radioligand and therefore that the amphetamine-induced increase in dopamine levels results in a reduction in radioligand binding and a change in the signal compared to baseline conditions. Stimulated dopamine release using amphetamine has consistently been found to be increased in psychotic conditions by 1–2 standard deviations, and is related to both the severity of induced psychotic symptoms, and to the response to subsequent antipsychotic treatment (Laruelle et al, Reference Laruelle, Abi-Dargham and van Dyck1996, Reference Laruelle, Abi-Dargham and Gil1999; Reference Breier, Su and SaundersBreier et al, 1997; Reference Abi-Dargham, Gil and KrystalAbi-Dargham et al, 1998). However this increased radioligand displacement has not been seen in patients with schizophrenia during remission, suggesting that the increased dopamine release is a feature of the psychotic phases of the illness (Reference Laruelle, Abi-Dargham and GilLaruelle et al, 1999).

These studies have been interpreted as indicating increased dopamine release, on the basis that animal studies show a correlation between increased dopamine concentration as measured by microdialysis and radiotracer binding (Reference Breier, Su and SaundersBreier et al, 1997; Reference Houston, Hume and HiraniHouston et al, 2004). To determine whether baseline levels of dopamine are different, Abi-Dargham and colleagues (Reference Abi-Dargham, Rodenhiser and Printz2000) examined the effect of dopamine depletion, using alpha-methyl-para-tyrosine, on [123I]IBZM binding (Reference Abi-Dargham, Rodenhiser and PrintzAbi-Dargham et al, 2000). They report greater [123I]IBZM binding following dopamine depletion in first-episode psychosis and patients with chronic disorder during an acute relapse compared with controls. This is taken as indicating greater baseline D2 receptor occupancy by dopamine in psychosis. Additionally the degree of change correlated with response to treatment with antipsychotics. Patients in remission need to be studied to determine whether this is related to illness phase.

Studies of presynaptic striatal dopaminergic function

Presynaptic striatal dopaminergic function can be measured using the PET radiotracers [β-11C]L-dopa and 6-[18F]fluoro-L-dopa (FDOPA). These radiotracers are converted by aromatic L-amino acid decarboxylase (AADC) into [11C]dopamine and 6-[18F]fluoro-dopamine, respectively, and trapped in vesicles in the presynaptic dopamine neurons. Their accumulation can be detected through the emission of annihilation photons as the radioisotopes decay via positron emission. Their uptake is typically quantified as an influx constant (Ki) value relative to a reference region devoid of specific uptake (Reference Patlak and BlasbergPatlak & Blasberg, 1985; Reference Moore, Whone and McGowanMoore et al, 2003; Reference McGowan, Lawrence and SalesMcGowan et al, 2004). High Ki values occur in areas of dense dopamine nerve terminals such as the striatum, reflecting the structural and functional integrity of the nigrostriatal dopaminergic system. Although tyrosine hydroxylase, and not AADC, is the rate-limiting step in the synthetic pathway for dopamine, AADC activity influences the rate of dopamine synthesis (Cumming et al, Reference Cumming, Kuwabara and Ase1995, Reference Cumming, Ase and Laliberte1997). FDOPA uptake has been shown to correlate with nigral dopamine neuron numbers in both animal and human studies (Reference Pate, Kawamata and YamadaPate et al, 1993; Reference Snow, Tooyama and McGeerSnow et al, 1993). These radiotracers have been used to investigate the dopaminergic system in a number of central nervous system conditions, particularly Parkinson's Disease (Reference BrooksBrooks, 1998; Reference Morrish, Rakshi and BaileyMorrish et al, 1998; Reference Piccini and BrooksPiccini and Brooks, 1999; Reference Brooks, Piccini and TurjanskiBrooks et al, 2000; Reference Rakshi, Pavese and UemaRakshi et al, 2002).

Eight studies have measured pre-synaptic striatal dopamine synthesis and storage capacity using [β-11C]L-dopa or FDOPA in psychotic conditions (Table 1). Six found elevated striatal DOPA uptake in psychotic disorders (Reference Reith, Benkelfat and SherwinReith et al, 1994; Hietala et al, Reference Hietala, Syvalahti and Vuorio1995, Reference Hietala, Syvalahti and Vilkman1999; Reference Lindstrom, Gefvert and HagbergLindstrom et al, 1999; Reference Meyer-Lindenberg, Miletich and KohnMeyer-Lindenberg et al, 2002; Reference McGowan, Lawrence and SalesMcGowan et al, 2004), with effect sizes in the positive studies ranging from 0.63 to 1.89. All studies that investigated patients who were psychotic at the time of PET scanning report elevated striatal dopamine synthesis capacity (Hietala et al, Reference Hietala, Syvalahti and Vuorio1995, Reference Hietala, Syvalahti and Vilkman1999; Reference Lindstrom, Gefvert and HagbergLindstrom et al, 1999). The two inconsistent studies were in chronically treated patients who were not acutely psychotic, although Dao-Castellana and colleagues (Reference Dao-Castellana, Paillere-Martinot and Hantraye1997) report a non-significant elevation in the striatum and greater variance in the Ki values in the group with schizophrenia (Reference Dao-Castellana, Paillere-Martinot and HantrayeDao-Castellana et al, 1997; Reference Elkashef, Doudet and BryantElkashef et al, 2000). The other study found a significant decrease in Ki value in the ventral striatum of the group with untreated schizophrenia, but an increase in the posterior cingulate (Reference Elkashef, Doudet and BryantElkashef et al, 2000). Thus all the studies have found indications of increased DOPA uptake in individuals with schizophrenia, although not all in the striatum.

Table 1 Summary of the radiolabelled DOPA PET studies in psychotic conditions, showing the DOPA uptake constants standardised to control values for the striatum (estimated from combined caudate and putamen values when not reported for whole striatum).

Study Radio tracer Illness length N patient group (M/F) N control group (M/F) Treatment Control group mean (s.d.) Patient group mean (s.d.) P 3 Effect size
Reference Reith, Benkelfat and SherwinReith et al, 1994 [18F] DOPA C 5 (5/0) 13 (9/4) 4 N, 1 DF 100±20 120±19 <0.02b 1.38
Reference Hietala, Syvalahti and VuorioHietala et al, 1995 [18F] DOPA All FE1 7 (4/3) 8 (6/2) All N 100±15 113±25 <0.05c 0.63
Reference Dao-Castellana, Paillere-Martinot and HantrayeDao-Castellana et al, 1997 [18F] DOPA Not listed 6 (6/0) 7 (7/0) 2 N, 4DF 100±11 108±42 NSb,c 0.27
Reference Hietala, Syvalahti and VilkmanHietala et al, 1999 [18F] DOPA All FE1 10 (4/6) 13 (8/5) All N 100±14 115±28 <0.05c 0.68
Reference Lindstrom, Gefvert and HagbergLindstrom et al, 1999 [11C] DOPA M2 12 (10/2) 10 (8/2) 10 N, 2 DF 100±17 113±12 <0.02b 0.88
Reference Elkashef, Doudet and BryantElkashef et al, 2000 [18F] DOPA C 19 (15/4) 13 (8/5) 9 DF, 10 A 100±11.5 984±9.8 NSb,c -0.20
Reference Meyer-Lindenberg, Miletich and KohnMeyer-Lindenberg et al, 2002 [18F] DOPA C 6 (5/1) 6 (5/1) All DF 100±9.2 119±11.5 <0.02a 1.89
Reference McGowan, Lawrence and SalesMcGowan et al, 2004 [18F] DOPA C 16 (16/0) 12 (12/0) All A 100±9.4 112±6.2 0.001a 1.57

Relationship between striatal dopamine synthesis capacity and symptom profiles

There are indications that the elevation in dopamine synthesis capacity is not specific to schizophrenia alone but is associated with episodes of positive psychotic symptoms. Reith et al (Reference Reith, Benkelfat and Sherwin1994) studied patients with complex partial seizures, and compared those with a history of psychosis to those who did not have a history of psychosis. The group with psychosis showed elevated striatal Ki values, similar to the elevation seen in a group with schizophrenia, while the striatal Ki value in the non-psychotic group was similar to that in controls (Reference Reith, Benkelfat and SherwinReith et al, 1994). Hietala and colleagues (Reference Hietala, Syvalahti and Vuorio1995) have suggested that there is a difference in FDOPA uptake which depends on the subtype of schizophrenia. This was based on the finding that a single subject with catatonia showed markedly lower striatal FDOPA uptake than controls and those with paranoid schizophrenia. Dao-Castellana et al (Reference Dao-Castellana, Paillere-Martinot and Hantraye1997) subsequently found a similar reduction in a subject with catatonia. Hietala and colleagues (Reference Hietala, Syvalahti and Vilkman1999) also found a negative correlation between depressive symptoms and striatal FDOPA uptake, and a trend for positive psychotic symptoms to be associated with higher striatal FDOPA uptake. Further support for elevated FDOPA uptake being associated with positive psychotic symptoms could be inferred from the two studies that found no significant elevation in striatal Ki value in chronic, stable patients (Reference Dao-Castellana, Paillere-Martinot and HantrayeDao-Castellana et al, 1997; Reference Elkashef, Doudet and BryantElkashef et al, 2000). However, elevated striatal Ki values have been reported in chronic patients in remission (Reference Reith, Benkelfat and SherwinReith et al, 1994), indicating that it is not as simple as acute psychosis being associated with increased dopamine synthesis capacity. McGowan et al (Reference McGowan, Lawrence and Sales2004) have found that dopamine synthesis capacity is elevated in individuals chronically treated for schizophrenia (Reference McGowan, Lawrence and SalesMcGowan et al, 2004) to a similar degree to that reported in antipsychotic-naïve patients in their first episode of psychosis (Hietala et al, Reference Hietala, Syvalahti and Vuorio1995, Reference Hietala, Syvalahti and Vilkman1999; Reference Lindstrom, Gefvert and HagbergLindstrom et al, 1999). Furthermore the findings reported by Hietala et al (Reference Hietala, Syvalahti and Vilkman1999) supporting an association between positive psychotic symptoms and elevated FDOPA uptake are at a trend level in small groups of patients, indicating that further studies are needed to determine if the association is found in other samples.

SPECIFICITY OF STRIATAL DOPAMINERGIC ABNORMALITIES TO PSYCHOSIS

Striatal dopaminergic function is not elevated in non-psychotic patients with other psychiatric or neurological conditions, including mania (without psychotic symptoms), Tourette's syndrome and depression (Reference Reith, Benkelfat and SherwinReith et al, 1994; Reference Turjanski, Sawle and PlayfordTurjanski et al, 1994; Reference Ernst, Zametkin and MatochikErnst et al, 1997; Reference Martinot, Bragulat and ArtigesMartinot et al, 2001; Reference Parsey, Oquendo and Zea-PonceParsey et al, 2001; Reference Yatham, Liddle and ShiahYatham et al, 2002). Ernst and colleagues report no significant difference in striatal FDOPA uptake between children or adults with attention-deficit hyperactivity disorder and controls, although there may be differences in other brain regions (Ernst et al, Reference Ernst, Zametkin and Matochik1998, Reference Ernst, Zametkin and Matochik1999). The findings in these studies indicate that elevated presynaptic striatal dopamine synthesis capacity is not a non-specific indicator of stress or psychiatric/neurological morbidity.

DOPAMINE AND THE PRODROMAL PHASE OF PSYCHOSIS

Prior to the development of psychosis, the majority of patients experience a prodromal phase characterised by functional decline and subclinical symptoms (Reference HafnerHafner, 1998). A number of instruments have been developed to prospectively identify people in this phase (Reference Hambrecht, Lammertink and KlosterkotterHambrecht et al, 2002; Reference Miller, McGlashan and RosenMiller et al, 2002; Reference Yung, Phillips and YuenYung et al, 2003). One of these, the Comprehensive Assessment of At Risk Mental State (CAARMS) (Reference Yung, Phillips and YuenYung et al, 2003), identifies people with an at-risk mental state using the Personal Assessment and Crises Evaluation (PACE) criteria who have a 20–40% probability of being in a prodromal state and developing a psychotic illness within 1 year, indicating that they are at ultra high risk of psychosis (UHRP). Most subjects meeting CAARMS criteria for an at-risk mental state experience ‘attenuated symptoms’, which correspond to positive psychotic symptoms that are not as severe and/or frequent as in an acute psychotic disorder. Less commonly individuals with an at-risk mental state experience brief limited intermittent psychotic symptoms (BLIPS), which are full-blown but brief psychotic episodes that spontaneously resolve after 1 week or less. The presence of positive psychotic symptoms in an at-risk mental state group defined using the CAARMS, albeit the psychotic symptoms show a lesser severity, frequency or duration than in acute psychotic disorders, is consistent with a perturbation of dopamine function. However, the at-risk mental state can be defined in different ways, and the CAARMS criteria are weighted towards positive symptoms relative to other features of the at-risk mental state, such as negative symptoms and subjective cognitive impairments (Reference Klosterkotter, Hellmich and SteinmeyerKlosterkotter et al, 2001; Reference Hambrecht, Lammertink and KlosterkotterHambrecht et al, 2002; Reference Ruhrmann, Schultze-Lutter and KlosterkotterRuhrmann et al, 2003).

Although molecular imaging studies provide evidence of striatal hyperdopaminergia in patients with an established psychotic disorder, no studies have been published to date using molecular imaging to assess striatal dopaminergic function before the onset of psychosis in people with an at-risk mental state, who are at high risk of imminently developing psychosis.

Subjects with an at-risk mental state are experiencing attenuated psychotic symptoms and are also at high risk of developing psychosis in the near future, therefore an initial prediction would be that the at-risk mental state would be associated with striatal hyperdopaminergia. However, as most individuals with an at-risk mental state will not develop a psychotic illness, a further prediction might be that the magnitude of this elevation will be greater in those that go on to develop a psychotic illness than in subjects who do not.

Models of psychosis (above) propose that elevated dopaminergic function may lead to the development of hallucinations and delusions through effects on cognitive processes like appraisal. Reasoning is a component of appraisal and those with at-risk mental state show a bias in probabilistic reasoning (‘jumping to conclusions’) that is similar to that seen in psychotic disorders (Reference Garety, Freeman and JolleyGarety et al, 2005; Reference Peters and GaretyPeters & Garety, 2006). This suggests that the magnitude of the hypothesised increase in dopaminergic function may be correlated with a tendency to jump to conclusions. In addition, because elevated dopaminergic function may be specifically linked to hallucinations and delusions, hyperdopaminergia in the at-risk mental state would be predicted to be particularly correlated with the severity of these symptoms as opposed to other psychotic features or the level of general psychopathology.

Finally, it has been suggested that the cognitive impairment and negative symptoms of schizophrenia are a function of hypodopaminergia in the dorsolateral prefrontal cortex (Reference Abi-Dargham, Mawlawi and LombardoAbi-Dargham et al, 2002). It is difficult to assess cortical dopamine function using FDOPA due to its low signal-to-noise ratio in the cortex (Reference McGowan, Lawrence and SalesMcGowan et al, 2004). However, it has been proposed that hypodopaminergia in the dorsolateral prefrontal cortex in schizophrenia is related to excess subcortical dopamine levels (Reference TanakaTanaka, 2006), and striatal FDOPA uptake in patients with schizophrenia has been inversely correlated with dorsolateral prefrontal cortex activation during the Wisconsin Card Sort test (Reference Meyer-Lindenberg, Miletich and KohnMeyer-Lindenberg et al, 2002) and with impaired performance on the symbol-digit modalities test (Reference McGowan, Lawrence and SalesMcGowan et al, 2004). Thus the hypothesised increase in striatal dopaminergic function in the at-risk mental state may be inversely correlated with impaired prefrontal cortical function, as indicated through impaired performance on tasks of executive functions and by abnormal dorsolateral prefrontal cortex activation in functional neuroimaging studies.

FUNCTIONAL SUBDIVISIONS OF THE STRIATUM

The striatum shows a topographic organisation reflecting connections with the limbic, frontal executive and motor brain regions that does not correspond to traditional anatomical subdivisions into caudate, putamen and nucleus accumbens (Reference HaberHaber, 2003). Ventral areas of the striatum (the nucleus accumbens, and ventral caudate and putamen rostral to the anterior commissure) are part of limbic circuits involving medial prefrontal and orbitofrontal cortex, and thalamic loops, and have been termed the ‘limbic striatum’ (Reference Joel and WeinerJoel & Weiner, 2000; Reference Martinez, Slifstein and BroftMartinez et al, 2003). The dorsal areas of the caudate and putamen rostral to the anterior commissure and the post-commissural caudate form circuits involving the dorsolateral prefrontal cortex, and ventral anterior thalamus, and are involved in cognitive function (‘the associative striatum’) (Reference Joel and WeinerJoel & Weiner, 2000; Reference Martinez, Slifstein and BroftMartinez et al, 2003). Finally the post-commissural putamen (‘the sensorimotor striatum’) is linked to the motor and premotor cortex and ventral anterior thalamus (Reference Joel and WeinerJoel & Weiner, 2000; Reference Martinez, Slifstein and BroftMartinez et al, 2003).

Striatal functional connectivity suggests that the consequences of dopaminergic dysfunction may vary depending on the area of the striatum affected. Because of its place in circuits involving the dorsolateral prefrontal cortex, the associative striatum would be predicted to be critical to the cognitive processes leading to psychosis, and the cognitive dysfunction seen in schizophrenia. Recent advances in imaging technology have enabled these functional subdivisions to be delineated (Reference Martinez, Slifstein and BroftMartinez et al, 2003). Preliminary evidence has recently been presented indicating that the alpha-methyl-para-tyrosine induced increase in D2 receptor availability was significantly higher in the associative striatum of patients with schizophrenia, but not the other striatal subregions (Reference LaruelleLaruelle, 2006).

If dopaminergic dysfunction is driving the development of psychosis through cognitive effects, we would predict that the associative striatum would show the largest increase in dopaminergic function in people with an at-risk mental state, and that this would correlate with dorsolateral prefrontal cortex function, such as performance on working memory tasks.

IN VIVO STUDIES OF STRIATAL DOPAMINERGIC FUNCTION IN PEOPLE AT RISK OF PSYCHOSIS

Dopamine function has not been studied in individuals with an at-risk mental state, but there have been studies in other groups at increased risk of psychotic illness, notably the unaffected relatives of people with schizophrenia, and people with schizotypal personality disorder. D2 receptor levels have been found to be elevated in the caudate to an intermediate degree in the non-psychotic monozygotic co-twins of patients with schizophrenia compared to controls (Reference Hirvonen, van Erp and HuttunenHirvonen et al, 2005), although there was no evidence of alterations in the D1/D2 receptor ratio (Reference Hirvonen, van Erp and HuttunenHirvonen et al, 2006). People with schizotypal personality disorder, who can experience intermittent attenuated psychotic symptoms, have been found to have increased [11C]raclopride displacement following amphetamine challenge (Reference Abi-Dargham, Kegeles and Zea-PonceAbi-Dargham et al, 2004). Interestingly the authors note that the degree of [11C]raclopride displacement seen in the schizotypal personality disorder group was similar to that seen in remitted patients with schizophrenia, but much less than that seen in patients with acute psychosis.

The investigation of striatal dopaminergic function in individuals with an at-risk mental state has a number of advantages over further studies of striatal dopaminergic function in people with psychotic illnesses. Firstly it will help determine the time-point at which dopaminergic abnormalities occur, indicating whether dopaminergic abnormalities are primary or secondary to other factors. Similarly the relationship between dopaminergic function and cognitive processes thought to be related to the development of psychosis, and the development of the cognitive deficits seen in psychosis, can be investigated. Additionally the effects of antipsychotic drugs on dopaminergic function are not a complicating factor as this group is largely antipsychotic ïve, and a substantial proportion of individuals with an at-risk mental state are in the prodromal phase of a psychotic illness, which is not the case in other ‘risk groups’, such as relatives of those with schizophrenia or people with schizotypy, as these groups contain many individuals who may be trait carriers but who will not develop psychosis. There has been considerable debate concerning the ethics of offering people with an at-risk mental state antipsychotic medication to treat attenuated psychotic symptoms and reduce the risk of developing psychotic illness (Reference McGorry, Yung and PhillipsMcGorry et al, 2001; Reference Haroun, Dunn and HarounHaroun et al, 2006). Studies of the dopaminergic system in individuals with an at-risk mental state would indicate whether a dopaminergic abnormality that might be modified by antipsychotic treatment exists prior to the development of psychosis.

CONCLUSIONS

There is a fairly substantial and consistent body of in vivo molecular imaging evidence indicating that striatal presynaptic dopamine synthesis and synaptic dopamine availability is increased in psychotic illnesses. Striatal dopamine D2 receptor levels may also be modestly increased in people with psychotic illnesses, although there have been a number of inconsistent studies, and striatal D1 receptor levels are similar. The relationship between psychotic symptoms and dopaminergic function is less well established, as few studies have investigated this, and the results among those to have done so are inconsistent. Although the imaging data reviewed supports the dopamine hypothesis, the studies cannot exclude the possibility that the abnormalities in the dopamine system are secondary to other factors, such as glutamatergic dysfunction (Reference Laruelle, Kegeles and Abi-DarghamLaruelle et al, 2003). Studies in people with at-risk mental states, some of whom are in the prodromal phase of psychosis, are needed to determine whether the dopaminergic abnormalities found in psychotic illness are state or trait features. Furthermore these studies will enable a number of predictions about the relationship between dopaminergic abnormalities and cognitive biases and cognitive impairments commonly associated with psychosis to be tested. Investigating the pathophysiology of the prodromal phase is important both to understand the pathophysiology of psychosis and for the development of better treatments to prevent the development of psychosis and ameliorate symptoms in the prodrome.

Footnotes

Declaration of interest

None.

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Figure 0

Table 1 Summary of the radiolabelled DOPA PET studies in psychotic conditions, showing the DOPA uptake constants standardised to control values for the striatum (estimated from combined caudate and putamen values when not reported for whole striatum).

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