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Clinical analysis of relapsing polychondritis with airway involvement

Published online by Cambridge University Press:  02 February 2022

S-Y Zhai ,
R-Y Guo ,
C Zhang ,
C-M Zhang ,
H-Y Yin ,
B-Q Wang  and
S-X Wen Open the ORCID record for S-X Wen [Opens in a new window]
S-Y Zhai
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi, China
R-Y Guo
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi, China
C Zhang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
C-M Zhang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China Shanxi Key Laboratory of Otolaryngology Head and Neck Cancer, Taiyuan, Shanxi, China
H-Y Yin
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Kunshan Maternal and Child Health Hospital, Kunshan, Jiangsu, China
B-Q Wang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China Shanxi Key Laboratory of Otolaryngology Head and Neck Cancer, Taiyuan, Shanxi, China
S-X Wen*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University), Taiyuan, Shanxi, China
*
Author for correspondence: Dr Shuxin Wen, Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Bethune Hospital (aka Third Hospital of Shanxi Medical University), No. 99 Longcheng Street, Taiyuan 030000, Shanxi, China E-mail: [email protected]
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Abstract

Objective

To identify the clinical characteristics, treatment, and prognosis of relapsing polychondritis patients with airway involvement.

Methods

Twenty-eight patients with relapsing polychondritis, hospitalised in the First Hospital of Shanxi Medical University between April 2011 and April 2021, were retrospectively analysed.

Results

Fifty per cent of relapsing polychondritis patients with airway involvement had a lower risk of ear and ocular involvement. Relapsing polychondritis patients with airway involvement had a longer time-to-diagnosis (p < 0.001), a poorer outcome following glucocorticoid combined with immunosuppressant treatment (p = 0.004), and a higher recurrence rate than those without airway involvement (p = 0.004). The rates of positive findings on chest computed tomography and bronchoscopy in relapsing polychondritis patients with airway involvement were 88.9 per cent and 85.7 per cent, respectively. Laryngoscopy analysis showed that 66.7 per cent of relapsing polychondritis patients had varying degrees of mucosal lesions.

Conclusion

For relapsing polychondritis patients with airway involvement, drug treatment should be combined with local airway management.

Keywords

Polychondritis, RelapsingLarynxTracheaDiagnosisTreatment
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 1 , January 2023 , pp. 96 - 100
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr S-X Wen takes responsibility for the integrity of the content of the paper

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