Every so often, our understanding of the way things are in psychiatry needs a bit of a shake up. Take for instance the refutation of the mind/body dichotomy or the categorisation of disorders as functional or organic. It is these shifts in perspective, after all, that free up our thinking and allow our knowledge and skills to progress. This book very clearly lays down such a challenge.

With the help of many of the world's leading researchers in their fields, the editors bring together a summary of the current state of knowledge of the aetiology of affective disorders, cerebrovascular disease and cardiovascular disease. They draw on detailed research findings from epidemiology, the neurosciences and psychiatry to help explain the high levels of comorbidity of these disorders.

How useful is this conflation? I suspect that researchers in these related fields will welcome the opportunity to set their work in a broad context and will appreciate the many tips on methodology and useful recommendations on future directions for research. For clinicians contemplating reading this book, the potential return may not be so immediately obvious, as it is dense and repetitious at times. However, it deserves to be read by psychiatrists and physicians working with older adults, who are interested in the shifting understanding of these disorders and emerging therapeutic directions.

Many things in this book caught my attention – clues to the causes of treatment resistance in late-life depression, the emergence of apathy as a distinct psychiatric phenomenon with multiple causes, and a need to follow progress in cardio- and cerebrovascular medicine, to name but a few. As yet, there are no evidence-based treatment guidelines, but there are some early suggestions of favourable responses to antidepressant medication and even to dietary interventions. Not surprisingly, less is said of the role of psychological interventions, but there are exciting hints from the neurosciences that psychological treatments may actually bring about changes at the level of neuronal functioning.

Although there is much still to do in bringing together the fields of vascular diseases and affective disorders, this book achieves the editors’ aim of marking out the ground as it currently stands.