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Routine clozapine assay monitoring to improve the management of treatment-resistant schizophrenia

Published online by Cambridge University Press:  29 April 2021

David Kitchen ,
Alex Till Open the ORCID record for Alex Till [Opens in a new window]  and
Panchu Xavier
David Kitchen*
Affiliation:
Mersey Care NHS Foundation Trust, Liverpool, UK Mersey Internal Audit Agency, Liverpool, UK
Alex Till
Affiliation:
Health Education England (North West), Liverpool, UK
Panchu Xavier
Affiliation:
Mersey Care NHS Foundation Trust, Liverpool, UK
*
Correspondence to David Kitchen ([email protected])
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Abstract

Aims and method

Routine therapeutic drug monitoring in clozapine therapy has previously not been considered justifiable. Using observational data, the clinical utility of annual clozapine assay monitoring is explored within a large mental health trust.

Results

After the introduction of routine monitoring, the rate of clozapine assays rose to 2.3 per patient per year, with a consistent reduction in high-risk clozapine assays (<0.1 mg/L or >1.0 mg/L or any result more than 24 months old). High-risk assays are associated with a mortality rate of 31.6 deaths per 1000 patients, more than twice that of those within the target range (0.35–0.60 mg/L and conducted within the past 12 months) (P = 0.048).

Clinical implications

Routine clozapine assay monitoring has significant clinical utility. Our simple but targeted approach can be readily implemented to reduce the number of patients with high-risk clozapine assay levels, potentially reduce all-cause mortality and provide optimal treatment for those with treatment-resistant schizophrenia.

Keywords

Clozapinetreatment-resistant schizophreniaassay monitoringtherapeutic drug monitoringmortality
Type
Original Papers
Information
BJPsych Bulletin , Volume 46 , Issue 5 , October 2022 , pp. 267 - 270
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Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists

Clozapine is the gold standard and only licensed treatment available for treatment-resistant schizophrenia. It is bioequivalent across the available licensed brandsReference Couchman, Morgan, Spencer, Johnston and Flanagan1 and comparative clozapine serum and plasma assay concentrations are insignificant clinically.Reference Handley, Fisher, Subramaniam and Flanagan2

Therapeutic drug monitoring is not mandatory in any countryReference Nielsen, Young, Ifteni, Kishimoto, Xiang and Schulte3 and, following the initial titration period, the longer-term clinical utility of routine clozapine assay monitoring has been questioned,Reference Freeman and Oyewumi4–Reference Bleakley and Taylor6 with limited manufacturers’ guidance available.7 In the UK, only 50–60% of patients prescribed clozapine for more than 1 year have clozapine assay levels performed within 12 months.8

This article explores the introduction of routine therapeutic drug monitoring as a clinical tool to reduce high-risk therapeutic drug levels, support individualised therapeutic regimes and improve the management of clozapine therapy in treatment-resistant schizophrenia.

Method

All patients prescribed clozapine were identified across acute, community, low and medium secure mental health services within a large mental health provider in the UK that covers a core weighted population of 1.1 million individuals.

Clozapine assay sampling was uncontrolled and conducted over the course of routine clinical practice. Results were directly obtained from Viapath pathology services and independently analysed by the authors.

Four predetermined clozapine assay risk categories were established pragmatically, based on clinical utility and established consensus:Reference Bleakley and Taylor6

  1. (a) Group 1: Never conducted

  2. (b) Group 2: Target range (0.35–0.60 mg/L and conducted in the past 12 months)

  3. (c) Group 3: Low risk (0.1–0.35 mg/L or 0.6–1.00 mg/L and conducted in the past 24 months)

  4. (d) Group 4: High risk (<0.1 mg/L or >1.00 mg/L or any result conducted more than 24 months ago).

The frequency of clozapine assay monitoring and total number of patients prescribed clozapine were monitored from 1 January 2007 to 30 June 2020, with point prevalence surveys taken in 2011 and annually from 2015 onwards.

Patients with a diagnosis of schizophrenia (n = 780) or schizoaffective disorder (n = 94) were subclassified, with their clozapine adherence reviewed over a 5-year period from 1 July 2015 to 30 June 2020. Patients’ rationale for discontinuing clozapine was identified from their electronic patient record, and ongoing adherence confirmed through active blood monitoring service registration and enrolment with the trust's clozapine dispensary.

All patients with a diagnosis of schizophrenia or schizoaffective disorder between 1 January 2011 and 30 June 2020 who were prescribed clozapine at the time of death or who died within 6 months of clozapine discontinuation were included for mortality analysis. Patients’ most recent clozapine assay could only be reliably cross-referenced between 2015 and 2019.

Ethics board approval and informed consent were not required for this study.

Results

Frequency of clozapine assay monitoring

The frequency of clozapine assay monitoring has risen beyond the increase in clozapine prescriptions. As identified in Fig. 1, the clozapine assay monitoring rate has risen from 0.1 assays per patient per year in 2007 to 2.3 assays per patient per year projected at the end of 2020, following the implementation of a ‘clozapine prescribing and monitoring policy’ in the trust in 2016.

Fig. 1 Annual frequency of clozapine assays cross-referenced against the total number of clozapine assays performed and patients prescribed clozapine from 1 January 2007 to 30 June 2020.

Clozapine assay risk categories

Prior to the introduction of the clozapine prescribing and monitoring policy, 66% of patients had never had a clozapine assay performed and only 12% of monitored patients had a clozapine assay within the target therapeutic range.

However, as highlighted in Fig. 2, clozapine assay monitoring has subsequently increased. Following an initial spike in the high-risk group as they were identified for the first time, this group has steadily declined, accounting for only 8% of patients in 2020.

Fig. 2 Distribution of patients in the clozapine assay risk categories before and after the implementation of a clozapine prescribing and monitoring policy in the trust in 2016.

There has similarly been a corresponding increase in the number of patients whose levels fall within the target or low-risk range (averaging 86% combined between 2016 and 2020), leaving the 2% of patients (n = 13) in 2020 who have never been tested, being almost exclusively those undergoing their initial titration.

Duration of clozapine therapy

In total, 874 patients with schizophrenia or schizoaffective disorder were prescribed clozapine between 1 July 2015 and 30 June 2020, equating to 79.5 individuals being prescribed clozapine per 100 000 people within our population.

Of these, 72.1% (n = 630) were prescribed clozapine throughout this period (with an average 9.6-year duration of clozapine adherence); 7.7% (n = 67) were transferred to another provider and therefore their duration of adherence is unknown; 14.5% (n = 127) had clozapine discontinued (with an average 4-year duration of adherence); and 5.7% (n = 50) died (with an average 10.7-year duration of adherence).

Of the 14.5% (n = 127) for whom clozapine was discontinued, 6% (n = 8) did not achieve a satisfactory therapeutic response to clozapine; 34% (n = 43) did not tolerate clozapine; 44% (n = 56) did not adhere to the clozapine regime; 13% (n = 17) received a red alert for clozapine-induced neutropenia or agranulocytosis; and 2% (n = 3) took an overdose on clozapine.

All-cause mortality cross-referenced with clozapine assay monitoring

In total, 91 patients (average age of 53 years) prescribed clozapine for a diagnosis of schizophrenia or schizoaffective disorder died between 1 January 2011 and 30 June 2020, giving a mortality rate of 15 per 1000 patients; 35% (n = 32) died with therapeutic clozapine assay levels and 65% (n = 59) with levels outside of the identified therapeutic range or never having had a clozapine assay conducted.

Mortality rates per 1000 patients were available between 2015 and 2019, with Fig. 3 highlighting significant differences. The high-risk group accounted for the highest mortality rate, at 31.6 deaths per 1000 patients, more than twice that of any other group, with 58% having a clozapine assay level >1.0 mg/L.

Fig. 3 Mortality rate per 1000 patients throughout 2015–2019 across the four clozapine assay risk categories, with P-values in relation to the high-risk group.

Comparing overall mortality before and after the introduction of the clozapine prescribing and monitoring policy (2011–2015 versus 2016–2019), we observed a very modest overall reduction in mortality, from 16.5 to 15.4 deaths per 1000, and a generally reducing trend over the 8-year duration studied.

Discussion

Higher clozapine assay levels expose individuals to greater risk of dose-related adverse effects,Reference Flanagan9 and although clozapine therapy in itself is thought to reduce all-cause mortality,Reference Tiihonen, Lönnqvist, Wahlbeck, Klaukka, Niskanen and Tanskanen10,Reference Vermeulen, van Rooijen, van de Kerkhof, Sutterland, Correll and de Haan11 there is a lack of evidence specifically considering the relationship between clozapine assay levels and mortality.

Through the implementation of a clozapine prescribing and monitoring policy, where clozapine assay monitoring was recommended at least annually, the trust grew to perform one of the highest frequencies of clozapine assay levels per annum for patients who have been prescribed clozapine for over 12 months.7

With routine clozapine assay monitoring, there has been a consistent reduction in the number of patients with high-risk clozapine assay levels and an increase in the number with levels within the target range. This is reassuring, because the mortality rate in the high-risk group is over twice the mortality rate for other groups, and an overall very modest reduction in all-cause mortality has been observed.

Limitations

This study was limited by the uncontrolled observational nature of its design, with data collection based on clinical interest over the course of routine clinical practice. Confounding factors influencing intra- and inter-individual clozapine assay variability were therefore unmeasured (with sample timing and smoking status likely to have the greatest effect). However, these findings remain novel and of significant clinical interest. In particular, there was an apparent rise in local prescribing confidence, as clozapine therapy increased 3% above the national average (9 v. 6%) between 2012 and 2018.12,13

Furthermore, of the 14.5% of patients for whom clozapine was discontinued, in 44% of these cases this was attributable to non-adherence. This supports findings elsewhere where it has been suggested that the fear of poor adherence may too commonly be used as a reason for not commencing clozapine13 and that clozapine has been significantly associated with lower rates of all-cause discontinuation compared with other oral second-generation antipsychotics.Reference Masuda, Misawa, Takase, Kane and Correll14

Clinical implications

Our analysis is one of the most comprehensive datasets of clozapine assay levels published to date. We highlight that routine clozapine assay monitoring in clozapine therapy has significant clinical utility for the well-educated clinician. It can reduce the proportion of patients with high-risk clozapine assay levels, improve the under-utilisation of clozapine therapy by improving prescriber confidence and, of significant clinical interest, can potentially contribute to reduced all-cause clozapine mortality.

About the authors

David Kitchen, BPharm, MSc, is Senior Clinical Pharmacist (Education and Training) with Mersey Care NHS Foundation Trust, and an associate consultant with Mersey Internal Audit Agency (NHS), Liverpool, UK. Alex Till, MBChB, MRCPsych, MSc, MBA, is a specialty registrar in forensic psychiatry with Health Education England (North West), Manchester, UK. Panchu F. Xavier, MBBS, PG Cert, MRCPsych, MSc, is Deputy Medical Director for Quality and Patient Safety with Mersey Care NHS Foundation Trust, Liverpool, UK.

Data availability

The data that supports the findings of this study are available on reasonable request from the corresponding author (D.K.). The data are not publicly available due to their containing information that could compromise patient confidentiality.

Acknowledgement

We thank Dr Steven Lane, lecturer in medical statistics at the University of Liverpool, for his kind and thoughtful advice regarding our analysis.

Author contributions

We confirm that all authors met the four ICMJE criteria for authorship, being equally involved in the design, drafting and revision of the article.

Funding

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Declaration of interest

None.

References

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Figure 0

Fig. 1 Annual frequency of clozapine assays cross-referenced against the total number of clozapine assays performed and patients prescribed clozapine from 1 January 2007 to 30 June 2020.

Figure 1

Fig. 2 Distribution of patients in the clozapine assay risk categories before and after the implementation of a clozapine prescribing and monitoring policy in the trust in 2016.

Figure 2

Fig. 3 Mortality rate per 1000 patients throughout 2015–2019 across the four clozapine assay risk categories, with P-values in relation to the high-risk group.

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